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objective: human cytomegalovirus (hcmv) is a beta-herpesvirus that causes persistent infection in humans, as well as severe disease in fetuses and immunocompromised individuals. although hcmv is not currently causally implicated in human cancer, emerging evidence suggests that hcmv infection may be specifically associated with malignancies such as gliomas. gliomas are one of the most common bra...

abstract objective tumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. the main purpose of the present study is to determine the incidence, age, sex, location and histological diagnosis of cns tumors in children, less than 15 years of age, in the mofid children's hospital, i...

MRI plays a vital role to evaluate brain tumor diagnosis and treatment planning. However, the manual segmentation of image is strenuous. With development deep learning, large number automatic methods have been developed, but most them stay in 2D images, which leads subpar performance. Aiming at segmenting 3D MRI, we propose model for with multiple encoders. Our reduces difficulty feature extrac...

Background: Solitary fibrous tumor (SFT) is a mesenchymal tumor which is most commonly seen in the pleura; however it can be seen in other organs such as the meninge, gastrointestinal tract, soft tissue, bone, and skin. SFT should be differentiated from other mesenchymal tumors in these organs. Immunohistochemistry plays a pivotal role for the histopathologic diagnosis...

Oncogenic Yes-associated protein (YAP) 1 fusions have been recently identified in several cases of meningioma mostly involving pediatric patients. The meningiomas harboring YAP1-MAML2, which is the most frequent fusion subtype, exhibit activated YAP1 signaling and share similarities with NF2 (neurofibromatosis type 2 gene) mutant meningiomas. We reported a rare case atypical intraparenchymal YA...

Abstract Cancer is the second leading cause of death worldwide. Brain tumors count for one out every four cancer deaths. Providing an accurate and timely diagnosis can result in treatments. In recent years, rapid development image classification has facilitated computer-aided diagnosis. The convolutional neural network (CNN) most widely used models classifying images. However, its effectiveness...

Central nervous system primitive neuro-ectodermal tumors (CNS-PNETs), have recently been re-classified in the most recent 2016 WHO Classification into a standby catch all category, "CNS Embryonal Tumor, not otherwise specified" (CNS embryonal tumor, NOS) based on epigenetic, biologic and histopathologic criteria. CNS embryonal tumors (NOS) are a rare, histologically and molecularly heterogeneou...