Scutellariae radix (SR), also known as Huangqin, is the dried root of Scutellaria baicalensis Georgi (Lamiaceae). It is listed in the Chinese Pharmacopoeia and is one of the most widely used Chinese herbal medicines against bacterial infection of the respiratory and the gastrointestinal tracts. The main components of SR (and of all Scutellaria species) are baicalein, baicalin, and wogonin. Rhin...

Background Recent studies have demonstrated that structural changes in the airways characteristic of asthma, collectively referred to as airway remodeling, occur in young children even prior to the diagnosis of asthma. Young children who experience human rhinovirus (HRV)-associated wheezing illness within the first three years of life are at increased risk for the subsequent development of asth...

Hypocapnia constricts peripheral airways in vivo. This study investigated the role of airway smooth muscle in this phenomenon and the mechanism of hypocapnia-induced contraction in vitro. Isometric tension, intracellular pH (pHi) and intracellular free calcium concentration ([Ca2+]i) were measured in porcine airway smooth muscles suspended in organ baths in the presence of 5% or 0% CO2. In trac...

: Anastomotic complications following lung transplantation include those affecting one of the three anastomoses performed in usual technique for transplantation: bronchial, pulmonary artery, and venous anastomoses. Airway have declined over time, but still are associated with significant morbidity mortality. The main pathogenic factor to development airway is post-transplant bronchial ischemia....

Asthma is characterized by airway inflammation, bronchial hyperresponsiveness, and airway obstruction by bronchospasm and bronchial wall thickening due to smooth muscle hypertrophy. A rise in cytosolic free Ca2+ concentration ([Ca2+]cyt) may serve as a shared signal transduction element that causes bronchial constriction and bronchial wall thickening in asthma. In this study, we examined whethe...

Bronchial wall area percent (WA% = 100 × wall area/total bronchial cross sectional area) is a standard computed tomographic (CT) measure of central airway morphology utilized in smokers with chronic obstructive pulmonary disease (COPD). Although it provides significant clinical correlations, the range of reported WA% is narrow. This suggests limited macroscopic change in response to smoking or ...

Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways and increased bronchial hyperreactivity as are observed in human asthma. We employed a model of late-phase allergic pulmonary inflammation in mice to address the role of leukotrienes (LT) in mediating airway eosinophilia and hyperreactivity to methacholine. Allergen intranasal challenge in OVA-sensit...

Brusasco, Vito, and Riccardo Pellegrino. Invited Review: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness. J Appl Physiol 95: 1305–1313, 2003;10.1152/japplphysiol.00001.2003.—In vivo, the airway response to constrictor stimuli is the net result of a complex array of factors, some facilitating and some opposing airway narrowing, whi...

Riihimäki, M. 2008. Inflammatory Response in Equine Airways. Cytokines in Bronchial Epithelium and Bronchoalveolar Lavage Cells. Doctoral dissertation. ISSN 1652-6880, ISBN 978-91-85913-45-9 Non-infectious airway inflammation in horses is a common problem worldwide when horses are housed indoors. In this thesis the inflammatory pathways in equine airways, with special regards to the role of bro...

BACKGROUND The epithelial reticular basement membrane (Rbm) of the airway wall thickens in patients with asthma. However, whether the thickening parallels whole airway wall thickening, which limits airflow, is unknown. The aim of this study was to examine the correlation between the bronchial Rbm thickening and whole airway wall thickening in asthma. In addition, the association of Rbm and whol...