Background As a non-invasive parameter of lower airway inflammation, fraction of exaled nitric oxide (FeNO) concentration has been known to be related with bronchial hyperreactivity in asthma patient. FeNO may be increased in atopy related diseases (e.g. allergic rhinitis) but relationship of FeNO and development of allergic rhinitis in asthma is unknown. The aim of this study was to investigat...

Bronchial asthma is a chronic inflammatory disease affecting the bronchial mucosa. In asthma patients, the highest number of inflammatory cells, including eosinophils, are found in the small bronchi. According to the most recent 2006 report of the Global Initiative for Asthma, inhaled corticosteroids (ICS) remain the first-line treatment of chronic asthma. They are characterized by high lung de...

weeks with noninvasive measures of airway inflammation including exhaled nitric oxide (eNO), sputum induction with bronchial hyperreactivity testing, and exhaled breath condensate. Physicians who were unaware of the results of inflammatory measures made reductions in the steroid dose on the basis of clinical assessment and spirometry. Multiple logistic-regression models were used to determine t...

We describe the case of a 77-year-old woman, ex-smoker, with mild emphysema, and bronchial hyperreactivity, admitted 2 years earlier at another hospital for bronchospasm with severe concomitant heart failure, who required treatment with vasoactive amines and ventilation support. The clinical condition was associated with generalized T-wave negativity, inversion mild enzyme elevation and alterat...

АСТМА ТА АЛЕРГІЯ, No 1 • 2015 Bronchial asthma (BA) and recurrent bronchitis occupy the leading place among chronic and recurrent respiratory diseases in children age. Special importance of problem of these diseases gets in view of the provisions that recurrent respiratory diseases in children is the debut of chronic bronchopulmonary pathology of adult period of life [1, 16]. One of the importa...

BACKGROUND Tobacco smoke is a key risk factor for chronic obstructive pulmonary disease, but it may also alter the pathophysiology of asthma. In the present study, we analyzed whether tobacco smoke has acute or chronic effects on bronchial tone and whether it alters bronchial reactivity in vitro. METHODS Airways in murine lung slices were digitally recorded and the change in cross-sectional a...

STUDY OBJECTIVE This study examined the impact on children's respiratory health of a government air quality intervention that restricted the sulphur content of fuels to 0.5% from July 1990 onwards. DESIGN/SETTING/PARTICIPANTS This study examined the changes, one and two years after the introduction of the intervention, in airway hyperreactivity of non-asthmatic and non-wheezing, primary 4, 5,...

WINNING ABSTRACT: Continuous positive airways pressure (CPAP) is a well known and safe method of treatment patients with obstructive sleep apnoea syndrome (OSAS). The effects of CPAP administration on the upper respiratory tract are known. However its effects on the lower respiratory tract still needs to be determined. Studies on bronchial hyperreactivity in patients treated by CPAP are contrad...

Inhaled bacterial lipopolysaccharides (LPSs) induce an acute tumour necrosis factor-alpha (TNF-α-) dependent inflammatory response in the murine airways mediated by Toll-like receptor 4 (TLR4) via the myeloid differentiation MyD88 adaptor protein pathway. However, the contractile response of the bronchial smooth muscle and the role of endogenous TNFα in this process have been elusive. We determ...