OBJECTIVE To evaluate the potential of hyaluronic acid (HA)-coated bovine serum albumin nanoparticles (BSANPs) as a novel chondrocyte-targeting drug-delivery nanomedicine. METHODS The HA-BSANPs were characterized by dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and X-ray diffraction. Fluorescence imaging was used to visualize the distribution o...

Abstract Background Phytotoxins of various classes and origin are often found in their cationic form the soil environment thus, overall behavior may be strongly affected by all geosorbents presenting cation exchange capacity (CEC). In addition to organic carbon (SOC), clays exhibit great potential as sorbents for chemicals. Therefore, 52 compounds major phytotoxin alkaloids, terpenoids steroids...

S-Benzylhomocysteine, containing isotopic atoms, has proved to be a key intermediate in the synthesis of labeled methionine and related compounds (1). The need of the optically active isomers of these tagged compounds for various metabolic investigations has prompted us to work out a method for the resolution of S-benzylhomocysteine which would be particularly suitable for small quantities of S...

Pantai Pedelegan merupakan salah satu pantai kawasan wisata yang terletak di Kabupaten Pamekasan. Perairan Padelegan dekat dengan ekosistem mangrove, estuari dan berdekatan tambak garam. Ekosistem tersebut penunjang kesuburan perairan dapat diketahui dari kadar nutrient distribusi klorofil-a ada. Penelitian ini bertujuan untuk mengetahui nutrien biomassa fitoplankton serta hubungannya parameter...

This study investigated the reciprocal cross-interactions between two distinct allosteric sites on the M(4) muscarinic acetylcholine receptor (mAChR) in the absence or presence of different orthosteric ligands. Initial studies revealed that two novel benzimidazole allosteric modulators, 17-beta-hydroxy-17-alpha-ethy nyl-delta(4)-androstano[3,2-b]pyrimido[1,2-a]benzimidazole (WIN 62,577) and 17-...

Based on the molecular findings that many bitter taste receptors (T2Rs) are expressed within the same receptor cells, it has been proposed that bitter taste is encoded by the activation of discrete neural elements. Here we examined how a variety of bitter stimuli are represented by neural activity in central gustatory neurons. Taste responses (spikes/s) evoked by bathing the tongue and palate w...