نتایج جستجو برای: brunaueremmettteller bet

تعداد نتایج: 8813  

Journal: :Ecology letters 2014
Jennifer R Gremer D Lawrence Venable

In bet hedging, organisms sacrifice short-term success to reduce the long-term variance in success. Delayed germination is the classic example of bet hedging, in which a fraction of seeds remain dormant as a hedge against the risk of complete reproductive failure. Here, we investigate the adaptive nature of delayed germination as a bet hedging strategy using long-term demographic data on Sonora...

2014
Stuart W. J. Ember Jin-Yi Zhu Sanne H. Olesen Mathew P. Martin Andreas Becker Norbert Berndt Gunda I. Georg Ernst Schönbrunn

Members of the bromodomain and extra terminal (BET) family of proteins are essential for the recognition of acetylated lysine (KAc) residues in histones and have emerged as promising drug targets in cancer, inflammation, and contraception research. In co-crystallization screening campaigns using the first bromodomain of BRD4 (BRD4-1) against kinase inhibitor libraries, we identified and charact...

2012
Stefan Kofler Claudia Asam Ulrich Eckhard Michael Wallner Fátima Ferreira Hans Brandstetter

The ability of pathogenesis-related proteins of family 10 to bind a broad spectrum of ligands is considered to play a key role for their physiological and pathological functions. In particular, Bet v 1, an archetypical allergen from birch pollen, is described as a highly promiscuous ligand acceptor. However, the detailed recognition mechanisms, including specificity factors discriminating bindi...

2013
Deanna A. Mele Andres Salmeron Srimoyee Ghosh Hon-Ren Huang Barbara M. Bryant Jose M. Lora

Interleukin (IL) 17-producing T helper (T(H)17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation and activation results in autoimmune conditions. Using a characterized potent and selective small molecule inhibitor, we show that the bromodomain and extra-terminal domain (BET) fami...

Journal: :Journal of immunology 2009
Katarzyna Placek Sona Gasparian Maryaline Coffre Sylvie Maiella Emmanuel Sechet Elisabetta Bianchi Lars Rogge

T-bet is a key regulator controlling Th1 cell development. This factor is not expressed in naive CD4(+) T cells, and the mechanisms controlling expression of T-bet are incompletely understood. In this study, we defined regulatory elements at the human T-bet locus and determined how signals originating at the TCR and at cytokine receptors are integrated to induce chromatin modifications and expr...

Journal: :The Journal of Experimental Medicine 2006
Takashi Usui Jan C. Preiss Yuka Kanno Zheng Ju Yao Jay H. Bream John J. O'Shea Warren Strober

T helper type 1 (Th1) development is facilitated by interrelated changes in key intracellular factors, particularly signal transducer and activator of transcription (STAT)4, T-bet, and GATA-3. Here we show that CD4+ cells from T-bet-/- mice are skewed toward Th2 differentiation by high endogenous GATA-3 levels but exhibit virtually normal Th1 differentiation provided that GATA-3 levels are regu...

Journal: :International journal of clinical and experimental pathology 2014
Haiming Yu Junlan Yang Shunchang Jiao Ying Li Wei Zhang Jiandong Wang

PURPOSE T-box transcription factor 21 (T-bet) is a key lineage-defining transcription factor. The purpose of this study was to verify the relationship between expression in primary tumors and prognosis of breast cancer. METHODS T-protein expression was immunohistochemically detected on surgically-obtained tumor samples of 130 (stage I-III) invasive breast carcinomas from Chinese subjects, who...

Journal: :Proceedings. Biological sciences 2011
Andrew M Simons

Uncertainty is a problem not only in human decision-making, but is a prevalent quality of natural environments and thus requires evolutionary response. Unpredictable natural selection is expected to result in the evolution of bet-hedging strategies, which are adaptations to long-term fluctuating selection. Despite a recent surge of interest in bet hedging, its study remains mired in conceptual ...

Journal: :The Journal of Experimental Medicine 2007
Andrew M. Intlekofer Naofumi Takemoto Charlly Kao Arnob Banerjee Felix Schambach John K. Northrop Hao Shen E. John Wherry Steven L. Reiner

Immunity to intracellular pathogens requires dynamic balance between terminal differentiation of short-lived, cytotoxic effector CD8+ T cells and self-renewal of central-memory CD8+ T cells. We now show that T-bet represses transcription of IL-7Ralpha and drives differentiation of effector and effector-memory CD8+ T cells at the expense of central-memory cells. We also found T-bet to be overexp...

2016
Federico Simonetta Amandine Pradier Eddy Roosnek

Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation...

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