Previous studies have shown that the glycoprotein orosomucoid modulates permeability of peripheral microvessels to charged molecules by contributing to the net charge on the microvessel wall. To investigate whether or not orosomucoid also modulates the permeability of the blood-brain barrier (BBB) by a similar mechanism, we measured the permeability (P) of rat pial microvessels to similar-sized...

Previous clinical research has suggested high-affinity binding of flavopiridol (FLAP) to human blood serum proteins, specifically either human serum albumin (HSA) or human alpha-1-acid glycoprotein (hAGP), when compared to fetal bovine serum albumin (BSA) or bovine alpha-1-acid glycoprotein (bAGP) used in pre-clinical assays. This high-affinity binding was suggested as the reason for its poor h...

THEORETICAL STUDIES OF COSMIC ACCELERATION

A theoretical analysis of the circuits for a nitrogen laser driven by the Blumlein or capacitor charge transfer transmission line is given in detail. The electrical characteristics of the charge line for a special case of resonant charging are discussed and the effects of various parameters on voltage and current are investigated. By using MICRO-CAP software the transient behavior of the curren...