Next-generation sequencing has enabled the genome-wide identification of human DNA replication origins. However, different approaches to mapping replication origins, namely (i) sequencing isolated small nascent DNA strands (SNS-seq); (ii) sequencing replication bubbles (bubble-seq) and (iii) sequencing Okazaki fragments (OK-seq), show only limited concordance. To address this controversy, we de...

PURPOSE During deep anterior lamellar keratoplasty (DALK), endothelium and Descemet's membrane are separated from the corneal stroma by intrastromal air injection ('big-bubble technique'). The aim of our study is to analyse histopathological changes in host corneal tissue caused by air insufflation in patients with keratoconus, their variability in 10 patients and their possible clinical implic...

Progress in imaging and quantification of tissue perfusion using ultrasound (US) and microbubble contrast agents has been undermined by the lack of an effective automatic attenuation correction technique. In this article, an elementary model of the US attenuation processes for microbubble contrast enhanced imaging is developed. In the model, factors such as nonlinear bubble scattering, nonlinea...

background : treatment procedures are the most common sources of pain in children. children with chronic diseases such as thalassemia experience many pains during painful procedures including at times of diagnosis, treatment and control of their disease. several methods have been reported to reduce pain. clinical professionals usually use distraction techniques to reduce pain. however, there is...

People have long been fascinated by bubbles and foams dynamics, and since the pioneer work of Leonardo da Vinci in the early 16th century, this subject has generated a huge bibliography. However, only very recently, much interest was devoted to bubbles in champagne wines [1]. Small bubbles rising through the liquid, as well as a bubble ring (the so-called collar) at the periphery of a flute pou...

A new recursive regression methodology is introduced to analyze the bubble characteristics of various financial time series during the subprime crisis. The methods modify a technique proposed in Phillips, Wu, and Yu (2011) and provide a technology for identifying bubble behavior with consistent dating of their origi-nation and collapse. The tests serve as an early warning diagnostic of bubble a...

A Lagrangian-Eulerian numerical scheme for the investigation of bubble motion in turbulent flow is developed. The flow is analyzed in the Eulerian reference frame while the bubble motion is simulated in the Lagrangian one. Finite volume scheme is used, and SIMPLEC algorithm is utilized for the pressure and velocity linkage. The Reynolds stresses are modeled by the RSTM model of Launder. Upwind ...