the major lipoprotein classes are heterogenous. human serum high-density-lipoproteins (hdl) are separated into two major subfractions (hdl2, d=1.063-1.125 g/ml, hdl3, d=1.125-1.210 g/ml) by a simple double precipitation method. there was a strong inverse relation between hdl-cholesterol (hdl-c) and subfractions hdl2-c and hdl3-c with atherosclerosis. this study demonstrated that hdl-c (p<0.001)...

OBJECTIVE Dyslipidemia in patients with coronary vasospasm may be characterized by low level of high-density lipoprotein (HDL)-cholesterol as well as apolipoprotein (apo) A-I but not high level of low-density lipoprotein-cholesterol. This study sought to examine the HDL particle size in patients with variant angina. METHODS The HDL particle size was examined by analyzing serum lipid levels in...

Turks have strikingly low levels of high density lipoprotein cholesterol (HDL-C) (10-15 mg/dL lower than those of Americans or Western Europeans) associated with elevated hepatic lipase mass and activity. Here we report that Turks have low levels of high density lipoprotein subclass 2 (HDL(2)), apoA-I-containing lipoproteins (LpA-I), and pre-beta-1 HDL and increased levels of HDL(3) and LpA-I/A...

Response to Simvastatin Therapy in Scandinavian Simvastatin Survival Study (4S) To the Editor: Ballantyne et al1 compared the coronary heart disease (CHD) event rate and the response to simvastatin therapy in a subgroup of approximately 500 individuals from the Scandinavian Simvastatin Survival Study (4S) study with “isolated increased LDL-C” with a similarly-sized subgroup that had not only an...

Amaç: Bu çalışmanın amacı, yeni birer belirteç olan; ortalama trombosit hacmi (MPV)/yüksek dansiteli lipoprotein (HDL) ve eritrosit dağılım (RDW)/HDL oranları ile obstrüktif uyku apne sendromu (OUAS) varlığı şiddeti arasındaki ilişkiyi değerlendirmektir. Gereç Yöntem: Ocak 2017 Mart 2020 arasında polisomnografi yapılan sonuçlarına eksiksiz ulaşılabilen 510 hasta çalışma yapılmıştır. Tiroid horm...

The plasma concentration, particle size, and chemical composition of high density lipoproteins (HDLs) are associated with the metabolism of triglyceride-rich lipoproteins (TGRLs). During alimentary lipemia there is active exchange of lipids and apolipoproteins between HDL and apolipoprotein B-containing lipoproteins. Whereas HDL has been assigned a protective role against the development of ath...

the purpose of the study was to determine the effect of fasting on physical abilities and body lipid levels of university students. therefore, 18 fasting students (9 male and 9 female) and 18 non-fasting students (9 male and 9 female) were randomly selected and tested for the following variables before and after ramazan month: blood sample of chol- total, trig, chol/ hdl, ldl and sfm of hand an...

Atherosclerotic cardiovascular disease is the major killer in industrialized societies. Treatment of this disorder via LDL lowering, particularly with statin drugs, has been partially effective but no panacea. Many patients developing coronary heart disease (CHD) do not have markedly elevated LDL but rather have low HDL levels, alone or accompanied by hypertriglyceridemia. The strong inverse re...

Endothelial lipase (EL) is a phospholipase with little triacylglycerol lipase activity. To assess structural and functional properties of EL-HDL (EL-modified high-density lipoprotein), HDL was incubated with conditioned medium from Cos-7 cells infected with adenovirus encoding human EL. After re-isolation of HDL by ultracentrifugation, TLC and HPLC analyses revealed that EL-HDL was markedly dep...

Prebeta-1 HDL is a molecular species of plasma HDL of approximately 67 kDa mass that contains apolipoprotein A-I, phospholipids, and unesterified cholesterol. It participates in a cyclic process involved in the retrieval of cholesterol from peripheral tissues. In this cycle, unesterified cholesterol from cells is incorporated into prebeta-1 HDL, providing a substrate for esterification of chole...