We assessed the feasibility of cardiac contractility modulation (CCM) by electric currents applied during the refractory period in patients with heart failure (HF). Extracellular electric currents modulating action potential and calcium transients have been shown to potentiate myocardial contractility in vitro and in animal models of chronic HF. CCM signals were biphasic square-wave pulses with...

Compliant Mechanisms (CMs) have been a hot research spot in recent years due to their distinguished mechanism concept from conventional rigid-body mechanisms: CMs can transfer motion, force, and energy only through the deflection of flexible components. Therefore, accurate efficient kinetostatic modeling for these elementary components plays rather important role regarding conducting synthesis ...

In this study, we explore the mechanics of a bigon and ring from combination experiments numerical simulations. A is simple elastic network consisting two initially straight strips that are deformed to intersect with each other through fixed intersection angle at end. novel multistable structure composed series bigons arranged form loop. We find usually contains several families stable states o...

A probabilistic framework for studying single-particle diffusion in partially absorbing media has recently been developed terms of an encounter-based approach. The latter computes the joint probability density (generalized propagator) particle position $\X_t$ and a Brownian functional ${\mathcal U}_t$ that specifies amount time is contact with reactive component $\calM$. Absorption occurs as so...

This work is devoted to prove the existence and uniqueness of solution BVP with non-local assumptions on boundary integral gluing conditions for parabolic-hyperbolic type equation involving Caputo derivatives. Using method energy, have been proved. Existence was proved by equations

Compliant Mechanisms (CMs) serve as a promising alternative for transferring motion, force and energy compared to rigid mechanisms. The mentioned desired function is achieved by making the most of elastic deflection all built-in flexible members in CMs, such slender straight beams initially curved (ICBs). Therefore, accurately characterizing deformation these plays considerable role modeling CM...

The traditional Database partitioning has failed in multi-tenant shared scheme database; this paper proposed a mixed Partitioning Approach. By integrating vertical and horizontal partitioning, we can adaptive expand the multi-tenant database according to the number of server nodes or we can make an optimal partitioning. Experimental results show that our approach can improve the performance of ...