There has been insufficient evidence on whether exposure to hypnotics affects the risk of type 2 diabetes (T2DM). The aim of this study was to examine patients with nonapnea sleep disorders using zolpidem, benzodiazepines (BZDs), or a combination of both, and their risk of T2DM. This was a population-based retrospective cohort study using data from 1997 to 2011. Data from the Taiwan National He...

The withdrawal syndrome from benzodiazepine (BZD) can be severe and in some cases may impede cessation of the use of the drug. We present here a case series of benzodiazepine detoxification by flumazenil infusion, stabilised with clonazepam. Patients were treated with flumazenil 1.35 mg/day for a median of 7 days. Self-reported physical withdrawal symptoms were recorded daily. In addition to fl...

PurposeWe performed this retrospective data bank analysis to evaluate the management of status epilepticus (SE) in prehospital setting and possible association treatment delay or insufficient approach with outcome.MethodWe evaluated all episodes a SE according our hospital record system between January 1st 2014 December 31st 2018. Classification ILAE classification 2015, Status Epilepticus Seve...

BACKGROUND Generalized triphasic waves (TPWs) occur in both metabolic encephalopathies and non-convulsive status epilepticus (NCSE). Empiric trials of benzodiazepines (BZDs) or non-sedating AED (NSAEDs) are commonly used to differentiate the two, but the utility of such trials is debated. The goal of this study was to assess response rates of such trials and investigate whether metabolic profil...

Editorial T his month Canadian Family Physician presents the results of a survey of Belgian family physicians, which was designed to elicit their attitudes toward prescribing benzodiazepines (BZDs) and the barriers they perceived to nonpharmacologic methods as alternative ways to manage stress, anxiety, and insomnia (page e398). Anthierens and colleagues 1 remind us how widespread the use of BZ...

mt at mf determined by cardiac catbeteriration l&up MA, gradient 440 mm Hg: Grwp IIB, @adknt ~40 mm Hg). %e pa,&& were matched wi,b 17 cnnlmt sub&w MI the basis of age, sex, be@, and intensity of exercise dting maximat exertion. Cardiac and stroke indexer were dctrnnined by the acetylene rebreaathing m&xl a, each exerciv level. Stroke wbmtc index in (xwp I w.w significantly greater at rest “he,...

The aim of this work is to elaborate a fast and reliable capillary electrophoresis method, for the separation of 1,4-benzodiazepine (BZD) derivates and their degradation products in acidic medium and in UV light. Because BZDs are neutral, hydrophobic compounds, the most efficient method proved to be micellar elektrokinetic capillary chromatography (MECC). For the separation we used a sodium tet...

Background Heterologous expression of α1, β2 and γ2S(γ1) subunits produces a mixed population of GABAA receptors containing α1β2 or α1β2γ2S(γ1) subunits. GABA sensitivity (lower in receptors containing γ1 or γ2S subunits) and the potentiation of GABA-activated chloride currents (IGABA) by benzodiazepines (BZDs) are dependent on γ2S(γ1) incorporation [1]. A variable γ subunit incorporation may a...

In this study on 99 outpatients who were being treated for alcohol and/or drug dependence and also using benzodiazepines (BZDs), prevalence rates of DSM-III-R and ICD-10 substance dependence diagnoses were ascertained and scalability, reliability and validity of the scales of the Benzodiaepine Dependence Self-Report Questionnaire (Bendep-SRQ) were assessed. The latter properties were investigat...