BACKGROUND The first-line treatment for resectable pancreatic cancer (RPC) is surgical resection. However, our patients have often experienced early recurrence after curative resection for RPC, with desperately poor prognosis. Some reports indicated that minimally distant metastasis not detected at operation might cause early recurrence. The present study aimed to identify preoperative clinicop...

AIM To retrospectively evaluate the factors that influence long-term outcomes of duodenal papilla carcinoma (DPC) after standard pancreaticoduodenectomy (SPD). METHODS This is a single-centre, retrospective study including 112 DPC patients who had a SPD between 2006 and 2015. Associations between serum levels of CA19-9 and CEA and various clinical characteristics of 112 patients with DPC were...

Although CA 19-9 is a tumour marker, high levels of CA 19-9 have also been reported in benign conditions such as acute cholangitis or pancreatitis. We present here a 56-year-old woman with complicated cholecystitis due to gallstone and elevated serum CA19-9 levels. After cholecystectomy procedure CA19-9 level returned to normal. The level of CA 19-9 should never be regarded as a gold standard b...

Introduction. Mature cystic teratoma is the benign tumor of the ovary. CA19-9 levels, although a marker of pancreatic malignancy, have been found to be raised in large ovarian mature cystic teratomas. Case Report. We report a case of a young female who had unusually high levels of CA19-9 in the blood associated with large ovarian mature cystic teratoma. The levels returned to normal 12 weeks af...

We investigated in this study the expression of ENO1 in tissues and plasma of PDAC patients to evaluate its clinicopathological and diagnostic significance. ENO1 protein expression was detected in tissue microarray of human PDAC and adjacent noncancer tissues. Electrochemiluminescence immunoassay and amplified luminescent proximity homogeneous assay (AlphaLISA) were performed to measure CA19-9 ...

OBJECTIVES: The tumor stage represents the single most important prognostic factor for colorectal cancer (CRC), although more accurate prognostics remain much needed. Previously, we identified CA125 as an independent significant factor, which have further validated along with CEA, CA19-9, and CA242 in a large cohort of CRC patients. METHODS: Using enzyme-linked immunosorbent assays, analyzed pr...

Tumour markers are widely used in clinical practice. Elevated tumour markers can be observed in both malignant and benign conditions. Therefore, it is important for clinicians to be aware of the association of tumour markers with various disorders so that unnecessary investigations can be avoided without missing the malignant disorders. A 58-year-old woman who presented with weight loss and ele...

症例は20歳の男性で，中学生の頃より左腹部痛を認めていた．2週間前より上腹部痛を認め，精査加療目的に当院に紹介となった．血液検査では，CA19-9 4,642U/mL，CA125 439U/mLと高値を認めた．画像上は左上腹部を中心に23×20cm大の巨大な嚢胞性病変を認め，肝臓や膵臓との連続性はなく，原発は脾臓と考えられた．腫瘍マーカーは高値であったが，画像上は壁在結節などの悪性を疑う所見は認めなかった．術前の経皮的穿刺細胞診では悪性細胞を認めず，嚢胞内容液中ではCA19-9 1,590,000U/mL，CA125 5,000＜U/mLと血清よりさらに高値であった．以上より，高CA19-9・CA125血症を呈した巨大脾嚢胞と診断し，腹腔鏡下脾臓摘出術を施行した．手術では，まず嚢胞内容液を吸引し術野を確保してから，脾臓を摘出した．病理組織検査にて類表皮嚢胞と診断され，術後の経過は良好...

Differentiating between periampullary carcinoma and chronic pancreatitis with an inflammatory mass is difficult. Consequently, 6% to 9% of pancreatic resections for suspected carcinoma are done inappropriately for chronic pancreatitis. Here, we test if matrix metalloproteinase 7 (MMP-7), a secreted protease frequently expressed in pancreatic carcinoma, can be measured in plasma, pancreatic, and...