The McCune-Albright syndrome was described as a syndrome of polyostotic fibrous dysplasia, café au lait skin pigmentation, and autonomous endocrine hyperfunction in 1937. We report a 17-year girl with early menarche and accelerated growth for the past three years. The endocrinological examination showed slight rise of growth hormone with other hormones in normal range. The CT showed an expansiv...

INTRODUCTION In this report we discuss an unusual cause of subarachnoid haemorrhage in association with neurofibromatosis. CASE PRESENTATION A previously fit 55-year-old man developed sudden onset headache with loss of consciousness. He was comatose on admission with no focal neurological signs. Numerous neurofibromas and café-au-lait patches were noted, indicating neurofibromatosis type 1 wh...

Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system and skin. Cutaneous manifestations of neurofibromatosis are characterized by café-au-lait macules, multiple neurofibromas, Lisch nodules and intertriginous freckling. Some benign or malignant tumors such as juvenile xanthogranuloma, pheochromocytoma, and malignant melanoma can...

provided the original work is properly cited. CC Type 1 neurofibromatosis, also referred to as von Recklinghausen's disease, is characterized by café-au-lait spots and benign cutaneous neurofibromas and is more common than type 2 neurofibromatosis [1,2]. In contrast, type 2 neurofibromatosis affects the central nervous system (CNS) via spinal cord tumors and bilateral vestibular schwannomas [1-...

Background and purpose: Moyamoya angiopathy (MA) is a progressive cerebrovascular disease with poorly understood pathophysiology. It mainly characterized by bilateral stenosis of the terminal intracranial part supraclinoid internal carotid arteries proximal parts middle anterior cerebral arteries. This results in early-onset ischemic or hemorrhagic strokes. The may be idiopathic (known as disea...

<p class="abstract">Type 1 neurofibromatosis (NF 1) may present with a constellation of symptoms but literature has recorded that the commonest manifestations are orthopedic spinal presentations taking lead. Of manifestations, scoliosis is frequently found compared to others which could include spondylolisthesis or defective pedicles and dural ectasia on radiographs. We reported 15-year-o...

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease with a prevalence of about1/3000. The clinical diagnosis NF1 based on the presence two or more followingcriteria: six café au lait spots, >2 neurofibromas any type, freckling in axillary oringuinal region, optic glioma, distinctive osseous lesion such as sphenoid dysplasia thinning oflong bone cortex without pseudoarthrosis, and...