Eleven volunteers participated in a study to characterize some physiological and psychological effects of caffeine in a double-blind, crossover study. During one week, the subjects were given a caffeine-containing beverage, and during a second week, they were given an identically appearing non-caffeine beverage. Data were accumulated based on urine tests and a medical examination. Diary entries...

Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed legal stimulant. The most potent form is over the counter oral tablets. The estimated average daily adult caffeine consumption is 300 mg. Rarely, serious toxicities such as seizure and cardiac arrhythmias have caused death. Caffeine concentrations of 80 mg/L are considered lethal. Cases investigated over 10 years by the Office of th...

CONTEXT Caffeine is the most commonly used psychoactive legal drug in the world. Caffeine's role in controlling pain has received less attention in the past, yet is being increasingly considered. This article briefly reviewed the literature to clarify the role of caffeine as a drug for pain control and attract investigators to this topic. EVIDENCE ACQUISITION The data on Caffeine as an adjuva...

Caffeine is regarded as a mild stimulant acting on the central nervous system that is responsible for a significant portion of the behavioural and physiological effects of coffee and tea. Motives why people take caffeine are reflected in consumption patterns. Early in the morning caffeine might help to wake up, whereas during the day it is an aid to stay awake or counteract fatigue. The intake ...

EPIDEMIOLOGIC STUDIES EXAMINing the association between coffee consumption and risk of myocardial infarction (MI) have been inconclusive. Coffee is a major source of caffeine (1,3,7-trimethylxanthine), which is the most widely consumed stimulant in the world and has been implicated in the development of cardiovascular diseases such as acute MI. However, coffee contains a number of other chemica...

BACKGROUND Intravenous adenosine is used to minimise the coronary micro-resistance to achieve maximal hyperaemia along with nitrates for optimal fractional flow reserve (FFR) measurements. We hypothesise that caffeine, being a competitive inhibitor of adenosine, would influence adenosine-mediated FFR readings. METHODS Consecutive patients undergoing angiogram and FFR measurements were enrolle...

background: weight loss and decreasing the body fat percentage (bf%) is motivated to optimize performance. in order to achieve these, many supplements are used by athletes, however the possible negative or synergic effects have not been fully described in the literature, specifically in humans. the present study was conducted to investigate the co-administration effects of two common used suppl...

HIGHLIGHTS • Adenosine induces a reduction in blood pressure, heart rate and renal flow. Caffeine (30 mg/kg) blocked all the cardiovascular changes induced by adenosine. The effect of caffeine lasts for 4 hours.

In a previous experiment, (-)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals. EGCG inhibited caffeine-induced cardiovascular activation measures, such as ...

Type 1 ryanodine receptor (RyR1) releases Ca2+ ions from the sarcoplasmic reticulum of skeletal muscle to initiate contraction. Multiple endogenous and exogenous effectors activate RyR1. Cryo-electron microscopy has identified binding sites three co-activators Ca2+, ATP caffeine, however, mechanism co-regulation synergy between these activators remains be determined. Here, we tested hypothesis ...