This 16-week study evaluated pharmacokinetics and pharmacodynamics of denosumab in 55 subjects with renal function ranging from normal to dialysis-dependent kidney failure. Participants received a single 60-mg subcutaneous dose of denosumab. Kidney function groups were based on calculations using the Cockcroft-Gault equation and U.S. Food and Drug Administration (FDA) guidance in place when the...

Calcium is one of the most abundant minerals in the body and its metabolism is one of the basic biologic processes in humans. Although historically linked primarily to bone structural development and maintenance, calcium is now recognized as a key component of many physiologic pathways necessary for optimum health including cardiovascular, neurological, endocrine, renal, and gastrointestinal sy...

CONTEXT AND OBJECTIVE Preeclampsia and neural tube defects can be prevented during pregnancy. Today, there is level I evidence showing that calcium supplementation during pregnancy may prevent preeclampsia and that use of folic acid may prevent neural tube defects. The aim here was to evaluate the proportion of patients undergoing prenatal follow-up who had received a prescription for calcium a...

BACKGROUND The aim of the present study was to examine the postprandial calcium and phosphate concentrations after supplementation with pentacalcium hydroxy-triphosphate (CaP). METHODS Ten men participated in this double-blind, placebo-controlled, cross-over study. The participants were divided into two groups. One group consumed bread enriched with CaP (plus 1 g calcium/d) and the other grou...

A preterm infant with hypophosphataemic rickets became hypocalcaemic when given milk specially formulated for preterm infants that contained increased phosphorus and calcium. The rickets resolved spontaneously. Routine calcium and phosphorus supplementation for preterm neonates should be investigated further.

This paper reviews two cornerstones of bone health: calcium and vitamin D. Recent recommendations on dietary intake and supplementation of calcium and vitamin D for prevention and treatment of osteoporosis are given.

Reports on the role of calcium on predisposition to cardiovascular disease have been rather inconsistent while studies on its interaction with other medications are ongoing. We therefore investigated the effect of separate and combine administration of calcium supplement with artemisinin-based combination drug on hepatic and serum lipid profile. Thirty two male wistar rats were randomly assigne...

Overall data from many studies carried out during the past 30 years show that dietary supplementation of children in developing countries may improve growth and development. Although the first few months and years of life have been considered key to these improvements, supplementation at any age may be able to influence bone health and physical development. There is considerable data in support...