The altered calcium binding activity of calmodulins (CaM) with point mutations can be restored toward that of wild type CaMs by the formation of a complex between CaM and a CaM binding sequence. Three different site-specific mutations resulted in selective effects on the apparent stoichiometry and affinity of CaM for calcium, with maintenance of the ability to activate myosin light chain kinase...

the aim of the current study was to assess the extent to which complementary and alternative medicine (cam) has been used in children and adults to treat seizures and to compare the perceptions and usage of cam between adult patients who decides for themselves and adults who decide for their sick children.in this cross-sectional study, patients who have been treated for epilepsy for at least on...

BACKGROUND More than one third of patients in the United States use complementary and alternative medicine (CAM); most also visit conventional physicians. There is little information about how physicians and patients discuss CAM. We hypothesized that physicians frequently fielded questions about CAM treatments but felt uncomfortable discussing them owing to a lack of education. OBJECTIVES To ...

The Community Atmosphere Model (CAM) has several well known biases that have important dynamical implications for research. Some examples of these biases include a cold temperature bias near the tropopause at high latitudes, systematic biases in the mean zonal wind, and transient momentum fluxes that are too strong. One method for investigating the impacts that these biases have is to use data ...

Content-addressable memory (CAM) is used to compare the search data with all the stored data in parallel. Due to the parallel comparison feature where a large amount of transistors are active on each lookup, however, the power consumption of CAM is usually considerable. There are two conventional CAM designs, i.e., NOR-type and NAND-type CAMs. The NOR-type CAM provides the best search performan...

Orai1 is a plasma membrane protein that in its tetrameric form is responsible for calcium influx from the extracellular environment into the cytosol in response to interaction with the Ca(2+)-depletion sensor STIM1. This is followed by a fast Ca(2+)·calmodulin (CaM)-dependent inhibition, resulting from CaM binding to an Orai1 region called the calmodulin binding domain (CMBD). The interaction b...

Individual neurons can express both the neural cell adhesion molecule (N-CAM) and the neuron-glia cell adhesion molecule (Ng-CAM) at their cell surfaces. To determine how the functions of the two molecules may be differentially controlled, we have used specific antibodies to each cell adhesion molecule (CAM) to perturb its function, first in brain membrane vesicle aggregation and then in tissue...

BACKGROUND Many targets of calcium signaling pathways are activated or inhibited by binding the Ca(2+)-liganded form of calmodulin (Ca(2+)-CaM). Here, we test the hypothesis that local Ca(2+)-CaM-regulated signaling processes can be selectively activated by local intracellular differences in free Ca(2+)-CaM concentration. RESULTS Energy-transfer confocal microscopy of a fluorescent biosensor ...

The output error of the globoidal cam mechanism can be considered as a relevant indicator of mechanism performance, because it determines kinematic and dynamical behavior of mechanical transmission. Based on the differential geometry and the rigid body transformations, the mathematical model of surface geometry of the globoidal cam is established. Then we present the analytical expression of th...

The output error of the globoidal cam mechanism can be considered as a relevant indicator of mechanism performance, because it determines kinematic and dynamical behavior of mechanical transmission. Based on the differential geometry and the rigid body transformations, the mathematical model of surface geometry of the globoidal cam is established. Then we present the analytical expression of th...