Multiple myeloma is a slowly proliferating disease of ‘mature B cells’, involving mainly the bone marrow. Active myeloma is often preceded by an indolent phase of monoclonal gammopathy of undetermined significance or smoldering myeloma. Although patients at this stage do not require therapy, genetically, the plasma cells are already very abnormal with the large majority of such patients having ...

The epidemiological study on the residents of the high background radiation areas in Yangjiang, China was started by Chinese scientists in 1972 and continued until 1986. In 1991, Japanese scientists recognized the importance of the work and a joint feasibility study was conducted with revised protocols. The feasibility study matured to a cooperative project involving both Chinese and Japanese s...

Thomas Fogle is Associate Professor and Chair of the Department of Biology at Saint Mary's College. He received his B.A. in Biology from Thiel College, M.A. in Zoology from Southern Illinois University at Carbondale, and Ph.D. in Genetics from North Carolina State University. He teaches introductory biology, genetics, and human genetics. His research interests include human cytogenetics, the cy...

A 5 day old male with bilateral anophthalmos, hypospadias, bifid scrotum, micrognathia, and cleft palate with normal chromosomes is described. There have been two case reports with similar clinical manifestations but associated with interstitial deletion of 14q (q22q23). We propose that either our patient represents a new syndrome or has a microdeletion which could not be detected on routine cy...

Chromosomal microarray technology represents the technical convergence of molecular genetics and cytogenetics, and is rapidly revolutionizing modern cytogenetics. Expected genomic aberrations are accurately identified and provide readily interpretable results that are suitable for clinical risk stratification and therapeutic strategies. The applic...

OBJECTIVE To determine the frequency of various cytogenetic aberrations in newly diagnosed chronic lymphocytic leukemia (CLL) patients, and their detection rate by cytogenetic and fluorescent In situ hybridization (FISH) technique separately. STUDY DESIGN A case series. PLACE AND DURATION OF STUDY Clinical and Molecular Cytogenetics Laboratories, University of California, Los Angeles, USA, ...

Cytogenetics, which is considered a fundamental tool to understand basic genetic and genomic issues of species, has greatly contributed to the description of polymorphisms both at inter- and intra-specific level. In fact, cytogenetics was one of the first approaches used to propose Anastrepha fraterculus (Diptera: Tephritidae) as a complex of cryptic species. Different morphological variants of...

Objective: In this paper, the authors describe the design, development and evaluationof specific simulation software for Cytogenetics training in order to demonstrate the usefulness of computer simulations for both teaching and learning of complex educational content. Background: Simulations have a long tradition inmedicine and can be very helpful for learning complex content, for example Cytog...

Cytogenetic methods are widely used during diagnosis in many types of hematological malignancies. Classical methods like karyotyping using GTG banding technique and molecular methods like fluorescent in situ hybridization (FISH) are still gold standard in clinics all over the world. According to WHO 2008 classification the cytogenetic analysis is the basic diagnostic tool during the diagnosis o...

Cytogenetic analyses in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have revealed a great number of non-random chromosome abnormalities. In many instances, molecular studies of these abnormalities identified specific genes implicated in the process of leukemogenesis. The more common chromosome aberrations have been associated with specific laboratory and clinical charact...