Candida tropicalis is a frequently isolated yeast species causing bloodstream, urinary tract and other infections particularly in patients admitted to intensive care units (ICUs) and those requiring prolonged urinary catheterization (UC) or receiving broad-spectrum antibiotics (BSA). This study investigated clinical characteristics and genetic relatedness among C. tropicalis strains isolated fr...

A 68-year-old woman, with a history of arterial hypertension, atrial fibrillation, and chronic liver disease due to HCV was hospitalized for bacteraemia and mechanical prosthetic mitral valve endocarditis associated with methicillinsensitive Staphylococcus aureus. She received antimicrobial therapy (cloxacillin, 6 guday and rifampicin 300 mguday for 6 weeks; gentamicin, 1 mgukguday for 2 weeks)...

BACKGROUND There is limited information in the literature on the presentation and prognosis of candidal urinary tract infection (UTI) in infants in the neonatal intensive care unit (NICU). METHODS This was a prospective cohort study performed in 13 Canadian NICUs. Infants with candidal UTI without extra-renal candidal infection at presentation were enrolled. RESULTS Thirty infants fit the s...

We used the Du Pont radioimmunoassay kit for soluble Legionella pneumophila serogroup 1 antigenuria (Du Pont Co., Wilmington, Del.) to test 422 urine samples from patients with and without Legionnaires disease (LD). The urine specimens were collected from 23 patients with culture-proven LD and from 346 patients without LD. L. pneumophila serogroup 1 was isolated from 14 patients with culture-pr...

Gut microflora contribute greatly to immune and nutritive functions and act as a physical barrier against pathogenic organisms across the gut mucosa. Critical illness disrupts the balance between host and gut microflora, facilitating colonization, overgrowth, and translocation of pathogens and microbial products across intestinal mucosal barrier and causing systemic inflammatory response syndro...

Background: During recent years, fungal infections have risen exponentially and are a cause of significant morbidity and mortality in hospitalized patients, especially in the critical care setting. There is paucity of data from India on fungal pathogens. Methods: We prospectively studied patients admitted to medical and surgical critical care section of a tertiary care institute in northern Ind...

background the ability of candida albicans to form biofilms and adhere to host tissues and biomaterial surfaces is an important factor in its pathogenesis. one of the main characteristics of biofilms is their resistance to broad-spectrum anti-microbial drugs. objectives in the present study the formation of biofilm by c. albicans from different sources was evaluated. in addition, the minimum bi...

BACKGROUND Asymptomatic bacteriuria (ABU) should only be treated in cases of pregnancy or in-patients undergoing urologic procedures; however, unnecessary treatment of ABU is common in clinical practice. OBJECTIVE To identify risk factors for unnecessary treatment and to assess the impact of an educational intervention focused on these risk factors on treatment of ABU. DESIGN Quasi-experime...

in the absence of deep organ involvement [6]—perhaps because drug penetration into infected organs is poorer, and drug concentration levels fall below those that are required to kill Candida species. To address the issue of homogeneity of the study population, analyses were also performed on subpopulations with can-didemia or with positive cultures of specimens from deep, normally sterile sites...