Multiple single-lever probes for scanning force microscopy arranged in a cassette design and made of a low-stiffness photoplastic material have been developed and successfully tested by imaging DNA molecules. The new concept consists of a column of a one-dimensional array of cantilevers with integrated tips, the first of which is used for imaging and the others are spares in case the first one ...

We present the design of a higher throughput "heart on a chip" which utilizes a semi-automated fabrication technique to process sub millimeter sized thin film cantilevers of soft elastomers. Anisotropic cardiac microtissues which recapitulate the laminar architecture of the heart ventricle are engineered on these cantilevers. Deflection of these cantilevers, termed Muscular Thin Films (MTFs), d...

This work presents a method for force calibration of rectangular atomic force microscopy (AFM) microcantilevers under heavy fluid loading. Theoretical modeling of the thermal response of microcantilevers is discussed including a fluid-structure interaction model of the cantilever-fluid system that incorporates the results of the fluctuation-dissipation theorem. This model is curve fit to the me...

Microfabricated cantilever beams have been used in microelectromechanical systems for a variety of sensor and actuator applications. Bimorph cantilevers accurately measure temperature change and heat flux with resolutions several orders of magnitude higher than those of conventional sensors such as thermocouples, semiconductor diodes, as well as resistance and infrared thermometers. The use of ...

We explore and exploit diffraction effects that have been previously neglected when modelling optical measurement techniques for the bending of micro-mechanical transducers such as cantilevers for atomic force microscopy. The illumination of a cantilever edge causes an asymmetric diffraction pattern at the photo-detector affecting the calibration of the measured signal in the popular optical be...

Abstract Deep cantilever beams, modeled using Timoshenko beam kinematics, have numerous applications in engineering. This study deals with the nonlinear dynamic response a nonprismatic characterized by considering deformed configuration of axis. The mathematical model is derived extended Hamilton’s principle under condition finite deflections and angles rotation. discrete motion constructed bas...

A polymeric micro-cantilever array has been developed that mimics the biological front-end processing in the mammalian cochlea, and is intended for use in applications of auditory prostheses. Made of optical epoxy polymer molded over a silicon substrate, the micro-cantilevers have similar mechanical performance as the basilar membranes in the mammalian ears. The polymeric cantilevers, which are...

Atomic force microscopy (AFM) is widely used in the biological sciences. Despite 25 years of technical developments, two popular modes of bioAFM, imaging and single molecule force spectroscopy, remain hindered by relatively poor force precision and stability. Recently, we achieved both sub-pN force precision and stability under biologically useful conditions (in liquid at room temperature). Imp...

Th e at om i c force micro scopy in ultrahi gh vacuum and at low temp erature demonstrated its excellent capabil i ty to reach atomic resolution . N evertheless in the case of biologi cal samples high resolution has been achieved only in very few cases. W e demonstrated here the imp ortance of the appropriate choice of prob es and substrates in order to image DN A at low temp erature w ith high...