Autonomic neuropathy has numerous causes, some of them common, such as diabetic autonomic neuropathy, and others rare, such as Fabry disease, but all can produce disabling symptoms. Autonomic neuropathy can affect the sympathetic, parasympathetic, and enteric branches of the autonomic nervous system to variable degrees, causing dysfunction of different organs such as heart, intestinal tract, an...

OBJECTIVE Measures of baroreflex sensitivity, heart rate variability (HRV), and the classical Ewing test parameters are currently used for the diagnosis of diabetic autonomic neuropathy and for mortality risk stratification after myocardial infarction. However, the strengths of the associations of these measures of autonomic function with risk of mortality have never been compared in one study ...

mitochondrial disorders (mids) require biochemical or genetic investigations for being diagnosed. in some cases, however, the diagnosis can be suspected upon the syndromic phenotype or upon clinical presentation and family history, as in the following case. the patient was a 74-year-old male admitted for worsening of pre-existing left-sided ptosis and ophthalmoparesis after a birthday party. th...

Cardiac autonomic neuropathy is most common secondary complication of diabetes mellitusis frequently undiagnosed and neglected even though it an independent predictor mortality morbidity. This phenomenon can be further exacerbated with co-morbidities like cirrhosis. High prevalence as well cirrhosis has been reported in Pakistan. However, proper knowledge information regarding incidence diabete...

The aim of this report was to study the cardiovascular autonomic tests in the evaluation of diabetic patients with gastroparesis. Forty diabetic subjects were divided into two groups: one group with gastroparesis (GP, n = 20) and another group paired by age and duration of diabetes without any complaint of autonomic neuropathy (DC, n = 20). They were evaluated clinically and submitted to a batt...

OBJECTIVE To determine the frequency of Cardiac Autonomic Neuropathy (CAN) in type-1 Diabetes mellitus patients and its association with the duration of disease and glycemic control. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY Department of Medicine, Liaquat University Hospital, Hyderabad/Jamshoro, from December, 2004 to April, 2005. METHODOLOGY Fifty patients of type-1 Di...

The pathophysiological mechanisms responsible for increased cardiovascular mortality in diabetic autonomic neuropathy are unknown. To investigate the effect of autonomic neuropathy on myocardial function, we performed dynamic contrast-enhanced magnetic resonance perfusion imaging during baseline conditions and after Dipyridamole-induced vasodilatation in nine type 1 diabetic patients with auton...

Autonomic neuropathy is associated with an increased incidence of silent myocardial infarction and sudden death. The purpose of this study was to investigate the prevalence of silent myocardial ischaemia in diabetic patients with autonomic neuropathy and without. Five standard autonomic function tests were performed on 41 men with diabetes: postural change in blood pressure, postural change in ...

Light-chain (AL) amyloidosis is the most common form of systemic and associated with an underlying plasma cell dyscrasia. The disease often difficult to recognise because its broad range manifestations what are vague symptoms. clinical syndromes at presentation include nephrotic-range proteinuria or without renal dysfunction, hepatomegaly, congestive heart failure autonomic sensory neuropathy. ...

BACKGROUND Cardiac autonomic neuropathy (CAN) is a serious complication of longstanding diabetes and is associated with an increased morbidity and reduced quality of life in patients with diabetes. The present study evaluated the prevalence of CAN diagnosed by reduced heart rate variability (HRV) using a newly developed device in a large, unselected, hospital-based population of patients with d...