Metastatic Crohn's disease, in which non-caseating granulomatous infiltration of the skin occurs at sites separated from the gastro-intestinal tract by normal tissue, is the least common dermatologic manifestation of Crohn's disease. We report a 15-year-old girl with metastatic Crohn's disease presenting as granulomatous vulvar papules and nodules with typical histopathologic features. To the b...

Idiopathic granulomatous mastitis (IGM) is a benign, chronic non-caseating breast disease, often mistaken for breast cancer. It usually affects women of child-bearing age. The treatment for IGM is inconclusive. In the past, surgical intervention was suggested due to the possibility of malignancy. However, in recent reports, corticosteroid therapy has been used with a good response. We present a...

Sarcoidosis is a systemic disorder of unknown etiology, characterized by non-caseating epitheloid granulomas. It has been suggested that sarcoidosis results from exposure to antigens like aerosols and infectious agents in genetically predisposed individuals [2]. Virtually any organ system may be involved. Although the involvement of the abdominal viscera is less frequent as compared to pulmonar...

Sarcoidosis is a systemic multiorgan disorder of unknown etiology characterized by a non-caseating granuloma reaction. Ocular involvement has been reported in 25-60% of the patients. Seven percent of the patients with sarcoidosis may first see an ophthalmologist due to ocular complaints. This report aims to present our diagnostic and treatment approach to a female patient with significant unila...

Sir, Common variable immunode¢ciency (CVID), one of the most frequent of the primary speci¢c immunode¢ciencies, is a heterogeneous group of syndromes characterized by a de¢ciency in antibody synthesis associated with panhypogammaglobulinaemia and recurrent bacterial infections (1). The occurrence of non-caseating granulomas in di¡erent organs, including the skin, has been described previously. ...

Background Sarcoidosis is a multisystem disease characterized by infiltration of tissues by non-caseating granulomas and cardiac disease associated with arrhythmias, conduction disturbances, heart failure and death. Previous case reports have described late gadolinium enhancement (LGE) in the right ventricle (RV), however, this has been interpreted to be a rare feature of cardiac sarcoidosis. W...

Sarcoidosis is a chronic inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, the involvement of eye and symptoms on the locomotor system. FMF (Familial Mediterranean Fever) is an autosomal recessive autoinflammatory disease, characterized by recurrent episodes of fever and polyserositis. ...

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by infiltration of non caseating granulomas in multiple organ systems. Sarcoidosis can have a plethora of cardiac manifestations which can mimic many other cardiovascular conditions ranging from asymptomatic electrocardiographic manifestations to life threatening arrhythmias resulting in sudden cardiac death. ...

The granulomas of sarcoidosis and non-caseating tuberculosis show similar cell-types: two forms of epithelioid cells, A and B, giant cells, lymphocytes and 'activated' mononuclear cells. The morphology of epithelioid cells suggests that they are primarily biosynthetic rather than phagocytic. The relationship of these various cells to each other is discussed and the following sequence of granulo...