"watershed effect," finding 10 to 15 years ofproblems all in 2 years due to an enhanced technology, or the common effect of increased findings that happens with many new screening or casefinding programs. In any event, as a direct result of screening sigmoidoscopies, three patients have had their cancers diagnosed at an earlier time than would have otherwise happened. Most importantly, four to ...

Recent genome-wide association studies (GWAS) have identified common genetic risk variants for chronic lymphocytic leukemia (CLL). Testing SNPs individually for an association in GWAS necessitates the imposition of a very stringent P value to address multiple testing. While this reduces false positives, it may result in true associations being missed. Thus, any overall estimate of the total her...

Phenolphthalein is frequently used laxative drug since 1930s, but the possible teratogenic effect of phenolphthalein was not checked in casecontrol eptedmiological study. In addition US Food and Drug Administration (FDA) declared the mutagenic and carcinogenic effect of phenolphthalein in 1999, thus we decided to evaluate the birth outcomes particularly congenital abnormalities (CAs) of newborn...

Previous studies on statin have revealed that increasing age, renal insufficiency, and concomitant medications were associated with rhabdomyolysis. However, there is a lack of analysis on the magnitude of such association in the Asia-Pacific region. The objectives of this study were to identify risk factors of statin-associated rhabdomyolysis in Thai patients and to evaluate the magnitude of as...

Abstrad Adenocarcinomas of the esophagus and gastric cardia were once rare. However, for unknown reasons, their incidence has been increasing rapidly over the past 15 years in the United States and parts of Western Europe. In contrast, the incidence of esophageal squamous cell carcinomas has remained relatively constant. To investigate possible reasons for these diverging incidence rates we ana...

Characteristics of cars, such as mass and age, play a significant role in crash severity, but their effect are difficult to quantify because of the great number of factors altering the outcome of a real world accident. In order to focus on the crashworthiness of cars, we examine risk factors of severity suffered by the drivers involved in two-car accidents recorded by the police between 1996 an...

The human intellect has an almost irresistible urge to categorize and simplify. Thus, over the years, heart failure has been classified as forward or backward, right or left, compensated or decompensated. These distinctions, which were made primarily on the basis of data obtained from the history and physical examination, provided a conceptual framework for thinking about heart failure and for ...

Epidemiological evidence strongly favors the notion that the risk of cardiovascular disease (CVD) is inversely related to the plasma high-density lipoprotein (HDL) cholesterol concentration.1 Low HDL cholesterol is still predictive of high CVD risk in subjects with low LDL cholesterol,2 as well as during statin treatment.3 These observational data and other studies, which show that HDL particle...

©FSRH J Fam Plann Reprod Health Care 2009: 35(4) Background Two studies recently published in the British Medical Journal, a retrospective cohort study using information from the Danish registries1 and the MEGA case-control study for which cases were identified via specialised anticoagulation clinics in The Netherlands,2 revisit the question of whether so-called ‘third generation’ combined oral...

In this issue of Cancer Research , two epidemiologic studies investigating the association between genetic variants on chromosome 8q24 and prostate cancer are published. The purpose of this editorial is to comment on the importance and implications of these findings and to explain the rationale of the journal for publishing not just one but two epidemiologic studies on 8q24 and prostate cancer....