Balance of physiological levels of iron is essential for every organism. In Aspergillus fumigatus and other fungal pathogens, the transcription factor HapX mediates adaptation to iron limitation and consequently virulence by repressing iron consumption and activating iron uptake. Here, we demonstrate that HapX is also essential for iron resistance via activating vacuolar iron storage. We identi...

In this study we investigated whether in plants, like in mammals, components of the nuclear cap-binding protein complex (CBC) are involved in nonsense-mediated mRNA decay (NMD). We selected several genes producing at least two alternatively spliced mRNA variants: one with a premature termination codon (PTC+) and another without it (PTC-). For each gene the PTC+/PTC- ratio was calculated using R...

The flow of genetic information from DNA to protein requires polymerase-II-transcribed RNA characterized by the presence of a 5'-cap. The cap-binding complex (CBC), consisting of the nuclear cap-binding protein (NCBP) 2 and its adaptor NCBP1, is believed to bind all capped RNA and to be necessary for its processing and intracellular localization. Here we show that NCBP1, but not NCBP2, is requi...

We demonstrate the first small area emitter (1.4 × 3 μm) N-p-n AlGaAs/GaAs HBTs fabricated with Nimplanted subcollectors in a high volume manufacturing environment. The subcollector region was defined by multiple N implants of various doses and energies on a semi-insulating GaAs substrate, and the remaining HBT layers were grown by MOCVD. To evaluate the impacts of Cbc reduction, devices with v...

A complete blood cell count (CBC) is one of the most common laboratory tests in medicine. For example, at our institution alone, approximately 1800 CBCs are ordered every day, and 10% to 20% of results are reported as abnormal. Therefore, it is in every clinician's interest to have some understanding of the specific test basics as well as a structured action plan when confronted with abnormal C...

Executive Summary: Capital Blue Cross is the largest health insurer in Central Pennsylvania and the Lehigh Valley, serving nearly 1.5 million members in a 21-county region. Capital Blue Cross customers with Comprehensive Major Medical and Wraparound Major Medical coverage can be assured their claims are handled as efficiently as possible through the CBC Sigma Omnidesk system and Pennsylvania Bl...

A Dammann grating is used as a spatial filter for a passive coherent beam combination (CBC) of three Yb-doped fiber amplifiers with an all-optical feedback loop. Using this diffractive-optics-based spatial filtering technique, we demonstrate CBC with 20 W output power, and the visibility of the far-field interference pattern is up to 88.7%. Measurements suggest that this approach is robust with...

The effects of conjoint behavioral consultation (CBC) and a structured homework program on math homework completion and accuracy in junior high school students (grades seven through nine) who were at risk for academic failure were investigated. A multiple baseline design across five participants was utilized. Follow-up data were collected approximately one month after CBC was completed, to asse...

Computer-based communication (CBC) has become an inevitable aspect of our infrastructure and a lasting alternative to face-to-face conversations. Yet, CBC (e.g. video conferencing) is not common practice for victim-offender mediation (VOM). Based on eighteen semi-structured interviews with adult victims, offenders mediators, we provide heuristic assessment applicability in VOM. Interviewees ass...

Control-based continuation (CBC) is a means of applying numerical continuation directly to a physical experiment for bifurcation analysis without the use of a mathematical model. CBC enables the detection and tracking of bifurcations directly, without the need for a post-processing stage as is often the case for more traditional experimental approaches. In this paper, we use CBC to directly loc...