Conventions: [DT] Dependency table; WU task colours (check, examine, other), EAL4 highlighted in case of multiple components in family. Abbreviations: beh. (behaviour), enf. (enforcing), ext. (extended), IF (interface), impl (implementation), interf. (interfering), mod. (module), pen (penetration), pot. (potential), req (requirement), s/e (supporting/enforcing), subs. (subsystem), sup. (support...

Introduction Many previous studies have observed atrophy and abnormal water diffusivity within the corpus callosum (CC) of multiple sclerosis (MS) patients [1, 2]. However, few studies have addressed the question whether such abnormalities exist in the earlier stages of MS, especially in clinically isolated syndrome (CIS). In this study, we aimed to investigate CC abnormalities in CIS patients ...