Progress in revascularization treatment of coronary artery disease (CAD) have triggered a growing interest for new non invasive imaging and localization of myocardial ischemia and viability [13]. Most recently magnetocardiographic (MCG) source imaging has received increasing attention for that purpose, as demonstrated by the relevant number of papers presented at this conference. Different MCG ...

The tumor suppressor p53 functions predominantly as a transcription factor by activating and downregulating gene expression, leading to cell cycle arrest or apoptosis. p53 was shown to indirectly repress transcription of the CCNB2, KIF23 and PLK4 cell cycle genes through the recently discovered p53-p21-DREAM-CDE/CHR pathway. However, it remained unclear whether this pathway is commonly used. He...

Liver progenitor cells (LPCs)/ductular reactions (DRs) are associated with inflammation and implicated in the pathogenesis of chronic liver diseases. However, how inflammation regulates LPCs/DRs remains largely unknown. Identification of inflammatory processes that involve LPC activation and expansion represent a key step in understanding the pathogenesis of liver diseases. In the current study...

We evaluate the mass function of virialized halos, by using Press & Schechter (PS) and/or Steth & Tormen (ST) expressions, for cosmologies where Dark Energy (DE) is due to a scalar self– interacting field, coupled with Dark Matter (DM). We keep to coupled DE (cDE) models known to fit linear observables. To implement the PS–ST approach, we start from reviewing and extending the results of a prev...

Evolutionary algorithms (EAs) excel in optimizing systems with a large number of variables. Previous mathematical and empirical studies have shown that opposition-based algorithms can improve EA performance. We review existing opposition-based algorithms and introduce a new one. The proposed algorithm is named fitness-based quasi-reflection and employs the relative fitness of solution candidate...

This paper develops a notion of capacity–delay–error (CDE) boundaries as a performance model of networked sources and systems. The goal is to provision effective capacities that sustain certain statistical delay guarantees with a small probability of error. We use a stochastic non-equilibrium approach that models the variability of traffic and service to formalize the influence of delay constra...

B- myb and cdc25C exemplify different groups of genes whose transcription is consecutively up-regulated during the cell cycle. Both promoters are controlled by transcriptional repression via modules consisting of an E2F binding site (E2FBS) or the related CDE plus a contiguous CHR co-repressor element. We now show that the B- myb repressor module, which is derepressed early (mid G1), is prefere...

The transcription factor p53 is central to cell cycle control by downregulation of cell cycle-promoting genes upon cell stress such as DNA damage. Survivin (BIRC5), CDC25C, and PLK1 encode important cell cycle regulators that are repressed following p53 activation. Here, we provide evidence that p53-dependent repression of these genes requires activation of p21 (CDKN1A, WAF1, CIP1). Chromatin i...

A non-classical route to the key CDE-ring fragment of the pectenotoxins has been developed which showcases a remarkable singlet oxygen-mediated cascade reaction sequence to install the complete DE ring system.

Background Few studies have documented the blood group antigens in the population of eastern India. Frequencies of some common alleles and haplotypes were unknown. We describe phenotype, allele, and haplotype frequencies in the state of West Bengal, India. Methods We tested 1,528 blood donors at the Medical College Hospital, Kolkata. The common antigens of the ABO, Rhesus, and Kell blood grou...