BACKGROUND In celiac disease (CD), intestinal epithelium damage occurs secondary to an immune insult and is characterized by blunting of the villi and crypt hyperplasia. Similarities between Hedgehog (Hh)/BMP4 downregulation, as reported in a mouse model, and CD histopathology, suggest mechanistic involvement of Hh/BMP4/WNT pathways in proliferation and differentiation of immature epithelial ce...

BACKGROUND Individuals with celiac disease (CD) are at increased risk of sepsis. The aim of this study was to examine whether CD influences survival in sepsis of bacterial origin. METHODS Nationwide longitudinal registry-based study. Through data on small intestinal biopsies from Sweden's 28 pathology departments, we identified 29,096 individuals with CD (villous atrophy, Marsh stage III). Ea...

INTRODUCTION the MYO9B gene contributes to the maintenance of the intestinal barrier and it has been postulated as a risk factor of celiac disease (CD). The objective of this study was to compare the frequency and association rs2305764, rs2305767 and rs1457092 MYO09B polymorphisms in pediatric CD patients from and. PATIENTS AND METHODS the study was made in 104 CD pediatric patients (Chilean ...

gluten associated disorders and the question around these associations has recently attracted attentions of many health professionals. this is because of high prevalence of undiagnosed gluten related disorders presenting with a multitude of symptoms and complications inside and outside small bowel. while the environmental factors associated with a complex genetics are leading to destructions of...

celiac disease (cd) is now considered a multiple and systemic immune-mediate disorder triggered by the ingestion of wheat gluten and related proteins. following the discovery of a link between gluten and cd, it was demonstrated that gliadin, one of the two principal protein groups comprising gluten, plays a key role in cd. it has since become clear that the different and crucial roles of gliadi...

Celiac disease, a permanent, irreversible but treatable disease is an autoimmune triggered by gluten ingestion in genetically predisposed individuals, also known as celiac sprue and sensitive enteropathy. Recent findingsIntestinal inflammation villous atrophy small intestines permanent intolerance to disesea leads seveare malabsorption. About 20%-38% patients were basically nutritionally imbala...

BACKGROUND Various ultrasonographic (US) signs have been reported in overt celiac disease (CD). The aim of this study was to investigate the diagnostic accuracy of 6 US parameters in predicting CD. METHODS One hundred sixty-two consecutive patients with chronic diarrhea (n=105), iron deficiency anemia (n=25), or dyspepsia (n=32) underwent anti-endomysial IgA antibody determination and duodena...

Celiac Disease (CD) is present in 1 to 16.4% of patients with diabetes mellitus type 1 disease. The most important serological markers of CD are anti-endomysial, anti-tissue transglutaminase (tTGA) and anti-glyadin antibodies. In this work, the frequency of tTGA in the Cuban population of diabetic patients was determined, by analyzing 208 subjects (116 male and 92 female; 19.04-years-old in ave...

INTRODUCTION The aim of the study was to translate, adapt and validate the Celiac Disease Questionnaire (CDQ), which was developed in Germany, for use in Turkey. METHODS The questionnaire was translated by a forward-backward translation method. Total CDQ score and four subscores (emotional state, gastrointestinal symptoms, worries, social problems) were calculated and their reliability assess...