Cell detection is the task of detecting approximate positions cell centroids from microscopy images. Recently, convolutional neural network-based approaches have achieved promising performance. However, these methods require a certain amount annotation for each imaging condition. This time-consuming and labor-intensive task. To overcome this problem, we propose semi-supervised cell-detection me...

During the global COVID-19 pandemic, the rate of mortality and morbidity was fairly low in Pakistan compared to western countries. Bacille Calmette-Guerin (BCG) vaccination provides cross-protection for a broad range of related and unrelated pathogens. This protection is attributed to the recognition of broadly cross-reactive Pathogen-Associated Molecular Pattern (PAMPS) like molecules. We inve...

We study the interplay between diversity and noise in a 3D network of FitzHugh-Nagumo elements, with topology dimensions chosen to model pancreatic beta-cell cluster, as an example excitable cell network. Our results show that are not equivalent sources disorder but have different effects on dynamics. Their synchronization mechanisms may act independently one another or synergistically, dependi...

 In recent years, researchers have been looking for genes whose products can directly affect the aging process. Among these, the anti-aging protein klotho has attracted much attention. This single transmembrane protein is expressed in the renal tissues, parathyroid gland and choroid network of the brain and acts as a co-receptor for Fibroblast Growth Factor FGF. In this way, it contributes to c...

in this paper, the focus is on a new kind of biodegradable semi-interpenetrating polymer networks, which derived from ɛ-caprolactone, lactide, 1,4-butane diisocyanate and ethylenediamine and also its potential has been investigated in soft tissue engineering applications. the polymers were characterized by nuclear magnetic resonance (nmr) spectrometry, fourier transform infrared spectroscopy (f...

Abstract T cells have a prominent role in the pathogenesis of atherosclerosis, although their exact function remains elusive. Here, we pursued network-driven approach to identify cell-associated gene programs driving transition from low- high-risk human plaques. In this study 43 carotid arterial plaques were collected and stratified based on absence (low-risk) or presence (high-risk) intraplaqu...

objective: tissue engineering is an (interdisciplinary field that applies polymeric scaffolds to control tissue formation in three-dinemtion (3d). the scaffold provides the microenvironment (synthetic temporary extracellular matrix) for regenerative cells, supporting cell attachment, proliferation, differentiation, and neo tissue genesis due to their suitable chemical, physical and biological s...

There are few reported cases of endobronchial metastasis of pheochromocytoma literature. We present here a 56-year old woman who underwent left lower lobectomy of lung, following pneumonia with unresolved chest radiographs. Computed tomography showed a lobulated soft tissue mass, measuring, 38×27 mm, at the perivascular space of anterior mediastinum. The resected specimen, showed lobulated tumo...