Introduction: Transplantation of bone marrow stromal cells (BMSCs) or Schwann cells (SCs) can increase axonal regeneration in peripheral nerve injuries. Based on our previous investigations, the goal of the present work was to examine the individual and synergistic effects of the two different cell types in sciatic nerve injury . We pursued to evaluate the effects of BMSCs and SCs co-transplant...

A low transitional-1 B cell IL-10/TNF? ratio predicts rejection and supports preemptive intervention for patients after kidney transplantation.

background: myeloablative-allogeneic stem cell transplantation is a common way of treating various malignant and nonma-lignant diseases; but, it is associated with hazardous immediate and late complications. the majority of patients are not good candidates for high dose therapy because of old age, medical co-morbidities or previous heavy treatments. the donor stem cells can engraft in the recip...

purpose: to investigate the efficacy of limbal-conjunctival autografting technique in patients with primary pterygium methods: fifteen eyes of 15 patients with primary pterygium underwent surgery for the removal of pterygium with limbal-conjunctival autograft. after the pterygium excision, the limbal portion of the graft was oriented and sutured to the limbus at the recipient bed with the epith...

Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...

Spinal cord injury (SCI) is well known as a severely disabling that can result in long-term neurological impairment and great impact on the social economic aspects of patients. To investigate controversy regarding Stem Cell Transplantation treatment modality to alleviate devastating effect Cord Injury, we performed literature research according PRISMA guidelines through Pubmed, Cochrane, EMBASE...

Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...

Neurogenic bladder (NGB) secondary to spinal cord injury (SCI) is accompanied with several complications such as urinary tract deterioration, urinary incontinence, and consequently lower quality of life (QoL), significant morbidities, and occasionally death. Current therapeutic methods have some side effects and there is no treatment for the upper urinary tract injuries. Stem cell therapy is a ...

Worldwide, organoids are being used in an increasing range and variety of research contexts, including certain forms drug testing transplantation research. In Korea, however, the ethical issues raised by organoid have received little attention there currently no laws or regulations governing this form Accordingly, study was conducted to identify examine challenges for The article is structured ...

Objective: Immune cells play important roles in mediating allograft rejection and tolerance after cardiac transplantation. However, immune cell heterogeneity at the single-cell level, how states shape transplantation immunity, remain incompletely characterized. Methods: We performed RNA sequencing (scRNA-seq) on LNs from a mouse syngeneic allogeneic model. Nine T clusters were identified throug...