The aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. Three independent variables selected were molar ratio of drug to lipid (X1), surfactant loading (X2) and volume of hydration (X3). Based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

The aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. Three independent variables selected were molar ratio of drug to lipid (X1), surfactant loading (X2) and volume of hydration (X3). Based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

this study is focused on developing an integrated optimization-simulation based genetic algorithm model (iosga) to develop the operational policies for a multi-purpose reservoir system. the objective function of the optimization model is considered to be a linear function of reliability (rel), resiliency (res), and vulnerability (vul) of the river-reservoir system. genetic algorithm (ga) is emp...

In order to improve the structural stiffness of gravure cell structure in solid printing process and realize a lightweight design, multi-objective optimization design method was proposed optimize parameters direct laser engraving structure. this paper, based on characteristics analysis contact force, ANSYS parametric language (APDL) used conduct finite element microstructure regular hexagonal c...

Grasping and manipulation force distribution optimization of multi-fingered robotic hands can be formulated as a problem for minimizing an objective function subject to form-closure constraints, kinematics, and balance constraints of external force. In this paper we present a novel neural network for dexterous hand-grasping inverse kinematics mapping used in force optimization. The proposed opt...

A detailed investigation into the analysis of beams with different boundary conditions. carrying either a moving mass or force is performed. Analytical and numerical techniques for determination of the dynamic behavior of beams due to a concentrated travelling force or mass are presented. The transformation of the familiar Euler-Bernoulli thin beam equation into a series of ordinary differentia...