Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic and HAM/TSP is the most common clinical manifestation of the virus. HAM/TSP is an inflamma...

The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and immune communications. Changes in one of the organs will affect the other organs. Disorders in the composition and quantity of gut microorganisms can affect both the enteric nervous system and the central nervous system (CNS), thereby indicating the existence of a microbiota-gut-brain axis. Due to the intric...

INTRODUCTION: Repairing the damaged nervous system is one of the greatest challenges facing regenerative medicine. Research into nervous system repair can be separated into two broad areas covering the central nervous system (CNS) and the peripheral nervous system (PNS). Damage to peripheral nerves can lead to loss of sensation, motor function and muscle weakness, but the PNS is capable of sign...

Neurocysticercosis (NCC) is a prevalent parasitic infection of the central nervous system (CNS) caused by Taenia solium larvae. It commonly found in developing countries with high incidence both NCC and CNS tuberculosis. In cases where patients have history pulmonary tuberculosis, lesions arising from can be misdiagnosed as tuberculomas. Furthermore, when papilledema (a sign raised intracranial...

Oral isotretinoin is a well-known, effective medication used in the treatment of severe cystic acne. While efficacious, potential side effects are often discussed and may cause concern for patients. Although most this mild, other more concerning adverse have been reported. Of note, has to affect central nervous system (CNS), causing headaches, pseudotumor cerebri, fetal CNS malformations. In co...

Systemic Lupus Erythematosus (SLE) is a complex clinical syndrome which its components are less clearly recognized and includes heterogeneous demonstrations engaging both central and peripheral nervous system along with disabling effects. This disease is called "thousand faces" due to these heterogeneous demonstrations. This gap exists while 75% of adults and children with SLE may dea...

in this investigation the effects of excess vitamin a administration during the early embryonic period were studied. intramuscular injection of a single dose of 15000,20000 or 25000 iu/kg vitamin a to pregnant balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (cns) including exencephaly, hydroc...

Polyomaviruses may cause human disease, particularly in immunocompromised hosts. JCV, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (PML), which occurs mostly in immunocompromised patients. Progressive Multifocal leukoencephalopathy (PML) is a progressive demyelinating disorder of the central nervous sy...