BACKGROUND The purpose of this study was to assess the repeatability and limits of agreement of corneal thickness values measured by a high-frequency ultrasound (Artemis-2), hand-held ultrasound pachymeter (DGH-500) and a specular microscope (SP-3000P). METHODS Central corneal thickness (CCT) was analyzed in this prospective randomized study that included 32 patients (18 men and 14 women) age...

OBJECTIVE: To evaluate the therapeutic effects of intra-vitreal injection Bevacizumab combined with Diclofenac-Na versus alone in treatment naïve diabetic macular edema. METHODS: In this prospective, randomized interventional clinical trial, 40 eyes participants were enrolled for trial conducted at an Ophthalmology department Qazi Hussain Medical Complex, Nowshera. Twenty each included and beva...

BACKGROUND DNA methylation in the promoter region of the glucocorticoid receptor gene (NR3C1) is closely associated with childhood adversity and suicide. However, few studies have examined NR3C1 methylation in relation to major depressive disorder (MDD) and hippocampal subfield volumes. We investigated the possible association between NR3C1 methylation and structural brain alterations in MDD in...

PURPOSE Many ocular parameters show strong heritable tendencies. The significance of central corneal thickness (CCT) in the context of glaucoma has been the subject of much debate recently, but its heritability has not been extensively explored. This study was designed to investigate the parent-child heritability of CCT among groups who have CCT considered to be at the extreme ends of the norma...

PURPOSE This meta-analysis was conducted to compare the intraoperative and postoperative outcomes of bimanual microincision cataract surgery (B-MICS) and coaxial microincision cataract surgery (C-MICS). METHODS Three databases were searched for papers that compared B-MICS and C-MICS from inception to June 2016. The following intraoperative and postoperative outcomes were included in the final...

PURPOSE The aim of this study was to compare 4 methods of central corneal thickness (CCT) measurements in terms of their agreement, repeatability, and measurement time. METHODS CCT was measured in 184 eyes of 92 healthy subjects by the same examiner. The methods used were as follows: noncontact specular microscopy (SM; Topcon SP-3000P; Topcon Corporation, Tokyo, Japan), Pentacam rotating Sche...

BACKGROUND To determine the change in central corneal thickness over time and whether the use of long-term topical antiglaucoma medications influences central corneal thickness. DESIGN Case control study with retrospective and prospective data collection. PARTICIPANTS One hundred eighty-seven eyes of 187 glaucoma patients (mean follow up 6.92 ± 1.67 years) being treated with topical antigla...

PURPOSE To examine if central corneal thickness (CCT) is different in emmetropia and high myopia. METHODS 57 emmetropic subjects (0 to + 1.5 D) and 48 high myopes (all more than - 6 D in spherical equivalent refraction) were studied. CCT was measured by a Haag-Streit Optical Low-Coherence Reflectometry (OLCR) pachymeter, a recently developed high precision pachymeter with a standard deviation...

Several properties of the human brain cortex, e.g., cortical thickness and gyrification, have been found to correlate with the progress of neuropsychiatric disorders. The relationship between brain structure and function harbors a broad range of potential uses, particularly in clinical contexts, provided that robust methods for the extraction of suitable representations of the brain cortex from...

From the results of the Ocular Hypertension Treatment Study emerged the conclusion that ocular hypertensive subjects with thinner central corneal thickness (CCT) are at increased risk of developing glaucoma. Although possible underlying biases that could have led to this conclusion are still under investigation, there is an increasing interest in the scientific community to understand the poten...