The Phadebact Pneumococcus Test is a coagglutination slide test for the serological identification of Streptococcus pneumoniae. Of 200 alpha-hemolytic streptococcal isolates, coagglutination test results agreed with those of optochin susceptibility and bile solubility in 189 cases, 105 of which were identified as S. pneumoniae by all three methods. The Phadebact test was 100% (113 of 113) sensi...

A rapid and sensitive direct spectrophotometric method for the determination of cerebrospinal fluid protein which usesas little as 0.1 ml. of sample has been described. The result is not affected by the ratio of albumin to globulin in the sample. Interfering substances are removed prior to spectrophotometric measurement with an automatic separation chamber employing the principle of gel filtrat...

A microfluidic device with integrated sample preparation is introduced for the detection of cerebrospinal fluid rhinorrhea—a condition resulting in leakage of CSF from the nose due to head trauma. While CSF rhinorrhea is a serious condition, current state-of-the-art diagnostics are expensive or slow (MRI, CT scan or ELISA). We show the capability of a microfluidic immunoassay to accept and proc...

Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc., of pharmaceuticals. In this article, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including, e.g., ant...

Soluble antigens of Haemophilus influenzae type b, Streptococcus pneumoniae, Neisseria meningitidis, and group B streptococcus were looked for in cerebrospinal fluid, serum, and urine by using the staphylococcal coagglutination test, latex agglutination test, and counterimmunoelectrophoresis. The staphylococcal coaggultination and latex agglutination tests were more sensitive than counterimmuno...

No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache ...

Tumor Treating Fields (TTFields) are non-ionizing alternating electric fields that have anti-cancer properties. After the initial approval for use in patients with recurrent glioblastoma 2011 and newly diagnosed glioblastomas 2015, they now being tested those advanced lung cancer, ovarian carcinoma, pancreatic cancer. Unlike ionizing radiotherapy, TTFields non-linear propagation characteristics...

In order to treat and/or control a disease or prevent its occurrence, first of all, physiological pathways must be understood very well. the previous 10 years, there has been lot interest in function exosomes intercellular communication, particularly studies on cancer and neurodegenerative disorders. This led plenty research this area. Exosomes are tiny transmembrane vesicles that produced by e...

Nonketot ic hyperglyc inaemia or nonketo t ic hyperglycinaemic encephalopathy (NKH) is an autosomal recessive inborn error of glycine metabolism with poor prognosis. The inherited defect of the glycine cleavage system leads to accumulation of glycine in body fluids, such as plasma, urine and particularly, cerebrospinal fluid (CSF). In the neonatal type, NKH generally presents with intractable s...

Immunoglobulins (Ig) in feline sera and secretions were identified by immuno-electrophoresis and immunodiffusion with rabbit antisera prepared to feline IgG, IgA, IgM, and whole serum. Adult cat sera, colostral whey, postcolostral sera, tears, and nasal secretions contained IgG, IgA, and IgM. IgG was the only Ig identified in precolostral sera and cerebrospinal fluid. Milk, intestinal contents,...