Alzheimer’s disease and related disorders are characterized by deposition of aggregated amyloid b-protein (Ab) and accompanying pathologic changes in the neuropil and in the walls of cerebral blood vessels. Ab induces neurotoxicity in vitro, and this effect is markedly enhanced when the peptide is preaggregated. Recently, we reported that freshly solubilized Ab1–42 can induce cellular degenerat...

Post-stroke movement disorders are uncommon, but comprise an important part of secondary movement disorders. These exert variable and heterogeneous clinical courses according to the stroke lesion and its temporal relationships. Moreover, the predominant stroke symptoms hinder a proper diagnosis in clinical practice. This article describes the etiology, treatment options and prognosis of post-st...

We followed 54 subjects with heterozygous familial hypercholesterolemia for an average of 10 (range 3-14) years. Half were treated surgically with partial ileal bypass and the other half (matched for age, sex, coronary heart disease, blood pressure, diabetes mellitus, smoking, obesity, and serum cholesterol concentration) were treated conservatively with diet and hypolipidemic drugs. The mean d...

Cerebrovascular disorders, particularly ischemic stroke, are one of the most common neurological disorders. High rates of overweight and obesity support an interest in the role of adipose tissue and adipose tissue releasing cytokines in inducing associated comorbidities. Adipokines can serve as a key messenger to central energy homeostasis and metabolic homeostasis. They can contribute to the c...

The issue of cerebral vascular pathology is one the most important social problems in modern world, and Russia no exception. Cerebrovascular diseases are distinguished by high prevalence, mortality disability rates. They great importance from a health perspective not only each individual, but total nation. Acute or chronic disorders circulation naturally results atherosclerosis major arteries h...

Screening for lower extremity peripheral arterial disease (PAD) is essential in assessing a patient’s risk of cerebrovascular disorders. The ankle-brachial index (ABI) widely used as screening tool PAD, but it can produce falsely normalized results due to factors like artery calcification and collateral vessels. We report patient with normal ABI confirmed PAD through ultrasound computed tomogra...

background and purpose: cancer and cerebrovascular accidents (cva) are two most common causes of mortality and morbidity in the elderly. patients with brain tumor can be highly affected by postsurgical stroke. cva may be the first manifestation in these patients . therefore, we aimed to assess the epidemiological factors affecting cva after brain surgery. methods: in this cross-sectional study ...