BACKGROUND Accumulating data point to intermediate-conductance calcium-activated potassium channel (IKCa1) as a key player in controlling cell cycle progression and proliferation of human cancer cells. However, the role that IKCa1 plays in the growth of human cervical cancer cells is largely unexplored. MATERIAL AND METHODS In this study, Western blot analysis, immunohistochemical staining, and...

AIMS To provide the basis for further exploring the effect and its mechanism of Death domain associated protein (Daxx) on the progress of cervical carcinoma induced by human papillomavirus (HPV), the distribution and location of Daxx in cervical carcinoma with high risk HPV(HR-HPV) positive was analyzed. METHODS The samples of normal cervical epithelial cells, cervical intraepithelial neoplas...

BACKGROUND Cervical cancer is one of the most common cancers in women worldwide, often associated with the infection of human papillomavirus (HPV). Toll-like receptor 8 (TLR8), a pattern recognition receptor, is involved in viral nucleic acid sensing. Recently TLR8 has been shown to be expressed in cancer cells, and it has been suggested that it may help cancer cell growth and tumor development...

The platelet-derived growth factor (PDGF) signalling pathway has been reported to play an important role in human cancers by modulating autocrine and paracrine processes such as tumour growth, metastasis and angiogenesis. Several clinical trials document the benefits of targeting this pathway; however, in cervical cancer the role of PDGF signalling in still unclear. In this study, we used siRNA...

Cervical cytological examination is the most widely applied screening method for cervical cancer and its precursors. Liquid-based cytology produces goodquality smears1 and enables the use of ancillary laboratory techniques to distinguish neoplastic from benign cells.1 Immunohistochemical and molecular markers have been tested to identify dysplastic cells in cervical smears. When testing for hum...

Cervical cancer is a major gynecological malignant tumor that threatens women's health. Current cytological methods have certain limitations for cervical early screening. Light scattering patterns can reflect small differences in the internal structure of cells. In this study, we develop light pattern specific convolutional network (LSPS-net) based on deep learning algorithm and integrate it in...

Dichloroacetate (DCA), a traditional mitochondria-targeting agent, has shown promising prospect as a sensitizer in fighting against malignancies including cervical cancer. But it is unclear about the effect of DCA alone on cervical tumor. Moreover, previous reports have demonstrated that the increased cyclooxygenase-2 (COX2) expression is associated with chemoresistance and poor prognosis of ce...

abstract background and aims: cervical cancer is among leading causes of cancer related death in women and human papilloma virus (hpv) is one of the important risk factor of this cancer. the aim of the present study was to develop a pcr method for identification of a high carcinogenic type of hpv, hpv 18 using e6 gene as a marker in patients with cervical cancer materials and methods: 92 formal...

The Werner (WRN) gene codes for a DNA helicase that contributes to genomic stability and has been identified as the gene responsible for progeria. Recent studies have shown reduced WRN expression due to aberrant DNA hypermethylation in cancer cells. Furthermore, WRN expression is thought to affect sensitivity to DNA topoisomerase I inhibitors in c...

Cervical cancer is one of the most prevalent malignancies in women, which has human papillomavirus infection as the major risk factor. Here we report the establishment of a new HPV-negative cervical cancer cell line and characterization of genetic alterations relevant to the pathogenesis of cervical cancer. A new cervical cancer cell line was established by extensive culture and natural selecti...