Cancer vaccine boost via the cervicovaginal rather than the intramuscular route of immunization appears to be crucial to induce genital CD8(+) T cells and tumor regression. This clinical activity is correlated with the ability of the mucosal boost to elicit resident memory T cells in the genital tract.

Vaginal dilation is proposed as the first choice treatment for patients with vaginal aplasia, but many patients with MRKH or Rokitansky syndrome (and cases with CAIS) may require a vaginoplasty. It is also necessary to make vaginoplasty in patients with vaginal or cervicovaginal atresia with a functional uterus before performing an utero-neovaginal anastomosis, also in trans-sexual men.

A 10 mM concentration of lithium does not interfere with reverse transcription (RT) or PCR. Sampling of cervicovaginal fluid by vaginal washing, with lithium (10 mM) in the washing buffer as a marker of dilution, may be utilized to accurately determine in HIV-infected women, by quantitative RT-PCR, the genital shedding of acellular HIV RNA at the level of the mucosa itself.

Preterm delivery (PTD) is the leading cause of infant morbidity and mortality. Epidemiological association between PTD and various bacteria that are part of the vaginal microflora has been reported. Bacterial vaginosis is believed to be a risk factor for preterm delivery. The aim of the present study is to investigate the association between bacterial vaginosis, cervicovaginal fetal fibronectin...

The role of the cervicovaginal (CV) microbiome in regulating cervical function during pregnancy is poorly understood. Gardnerella vaginalis (G. vaginalis) is the most common bacteria associated with the diagnosis of bacterial vaginosis (BV). While BV has been associated with preterm birth (PTB), clinical trials targeting BV do not decrease PTB rates. It remains unknown if G. vaginalis is capabl...