This report describes the application of mesh-subdivision algorithms in the context of CGA shape, a shape grammar for Computer Generated Architecture. Constituting a procedural modeling approach, CGA shape allows the creation of models under moderate effort, which can furthermore be varied easily by the possibility to parametrize the rules of CGA shape. At the Vienna University of Technology a ...

Different studies have shown that milk may interact with polyphenols and affect their bioavailability in humans. The present study investigated the effect of the simultaneous consumption of coffee and milk on the urinary excretion of chlorogenic acids (CGA) and metabolites. Subjects were submitted to consumption of water, instant coffee (609 mmol of CGA) dissolved in water, and instant coffee d...

Numerous clinical therapeutic agents have been identified as DNA damaging. The present study revealed that isoproterenol (Iso) resulted in DNA damage in vascular smooth muscle cells (VSMCs) and increased the levels of intracellular oxygen free radicals. Administration of chlorogenic acid (CGA) inhibited this effect. Pretreatment with CGA abrogated the increase in protein expression levels of γ‑...

Chromogranin A (CgA) is regarded as a major, nonspecific neuroendocrine tumour (NET) marker. The results of CgA blood concentration, however, may actually be influenced by various factors or coexisting pathological conditions. Among the factors causing a substantial increase of the blood CgA concentration are: treatment with proton-pump inhibitors or H2 -receptor blockers, chronic atrophic gast...

Comprehensive geriatric assessment (CGA) is a core and an essential part of the comprehensive care of the aging population. CGA uses specific tools to summarize elderly status in several domains that may influence the general health and outcomes of diseases of elderly patients, including assessment of medical, physical, psychological, mental, nutritional, cognitive, social, economic, and enviro...

Introduction. Comprehensive geriatric assessment (CGA) is used to personalize cancer treatments in frail older adults. However, its utility guide patients with diffuse large B-cell lymphoma (DLBCL) not well known. We performed a meta-analysis of evidence published this area. Material and methods. searched PubMed Google Scholar for studies between January 2000 2023 that included aged ≥ 65 years ...

Developing Coffea arabica seeds accumulate large amounts of chlorogenic acids (CGAs) as a storage form of phenylpropanoid derivatives, making coffee a valuable model to investigate the metabolism of these widespread plant phenolics. However, developmental and environmental regulations of CGA metabolism are poorly understood. In the present work, the expression of selected phenylpropanoid genes,...

BACKGROUND Most older adults living in long-term care facilities (LTCF) are frail and have complex care needs. Holistic understanding of residents' health status is key to providing good care. Comprehensive Geriatric Assessment (CGA) is a valid assessment method which aims to embrace complexity. Here we aimed to study a CGA that has been modified for use in long-term care (the LTC-CGA) and to i...

Cellular Genetic Algorithms (cGA) are spatially distributed Genetic Algorithms that, because of their high level of diversity, are superior to regular GAs on several optimization functions. Also, since these distributed algorithms only require communication between few closely arranged individuals, they are very suitable for a parallel implementation. We propose a new kind of cGA, called hierar...

10.1016/S1674-6384(14)60004-6 Objective To evaluate the protective effect of chlorogenic acid (CGA) on carbon tetrachloride (CCl4)-induced liver injury of rats. Methods The anti-oxidative activity of CGA was investigated with several established in vitro systems. The hepatoprotective activity of CGA against CCl4-induced acute liver injury in rats was studied. The levels of alanine aminotranfera...