Acknowledgment: We wish to thanks Dr D.W. Cope for critical comments. This work was supported by the Fondation NRJ-Institut de France, the Wellcome Trust (grant 071436) and the Fondo de Investigaciones Sanitarias (grant 03/0177). D.R. is supported by the Ramón y Cajal program from MCYT, Spain. We wish to thank Novartis (Basel, Switzerland) for their gift of CGP 55845A and CGP 35348. Page 1 of 2...

CGP 9000, (7-[D-2-amino-2-(1,4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine. Upon oral administration to mice infected with various bacteria, CGP 9000 is, in general, 2 to 7 times more effective ...

RATIONALE Aspartame (L-aspartyl phenylalanine methyl ester) is a non-nutritive sweetener (NNS) approved for use in more than 6000 dietary products and pharmaceuticals consumed by the general public including adults and children, pregnant and nursing mothers. However a recent prospective study reported a doubling of the risk of being overweight amongst 1-year old children whose mothers consumed ...

Polymorphic gates are unconventional circuit components that are not supported by existing synthesis tools. This article presents new methods for synthesis of polymorphic circuits. Proposed methods, based on polymorphic binary decision diagrams and polymorphic multiplexing, extend the ordinary circuit representations with the aim of including polymorphic gates. In order to reduce the number of ...

Los trastornos crónicos están asociados a desbalances en la actividad autónoma caracterizados por predominio simpático, el cual está relacionado con comorbilidades y empeoramiento de los síntomas. Se desea saber si esta condición existe pacientes Irapuato, Guanajuato. Mediante un muestreo accidental se incluyeron siete diagnóstico mayor año. Usando perfil psicofisiológico del estrés, simpática ...

Gut pigment content of the mesozooplankton community in Santa Monica Basin, California, USA was examined on 3 winter-spring and 3 autumn cruises between October 1985 and February 1988. Mean chlorophyll concentrations for the upper 70 m varied from 0.30 to 0.32 mg m-3 for autumn cruises and from 0.35 to 1.7 mg m-3 for winter-spring cruises. Larger crustacean zooplankton species, particularly the...

A positive association between renin-angiotensin system, especially AT1 receptor, and oxidative stress in the pathogenesis of hypertension and cardiovascular/renal diseases has been suggested. However, the role of oxidative stress, especially superoxide radicals in renal sodium handling in response to AT1 and AT2 receptors, is not known. Therefore, the present study was designed to investigate ...

We studied how mitochondrial Ca2+ transport influences [Ca2+](i) dynamics in sympathetic neurons. Cells were treated with thapsigargin to inhibit Ca2+ accumulation by SERCA pumps and depolarized to elevate [Ca2+(i); the recovery that followed repolarization was then examined. The total Ca2+ flux responsible for the [Ca2+](i) recovery was separated into mitochondrial and nonmitochondrial compone...

Studies on the relative contribution of β 1- and β 2-adrenoceptors (AR) generally employ selective β 1- and β 2-AR antagonists such as CGP 20712A and ICI 118,551, respectively, and assume that antagonism by one of these compounds indicates mediation by the respective AR subtype. Here, we evaluated the β 2-AR-selectivity of ICI 118,551 in ventricular muscle strips of transgenic mice lacking β 1-...