OBJECTIVES To investigate the association between single nucleotide polymorphisms (SNPs) in the adiponectin-encoding gene ADIPOQ and changes in serum lipid levels in HIV-1-infected patients after antiretroviral therapy (ART). METHODS ART-naïve HIV-1-infected patients were recruited to this prospective analysis. SNP +45 and SNP +276 genotype was determined by direct sequencing. Multivariate li...

Background: The present study was conducted to determine the prevalence of metabolic syndrome (Mets) in schizophrenic patients in a 6-month period of treatment with antipsychotic medication. Methods: In this study, 60 volunteer schizophrenic patients were included.  At the onset and 6 month after treated with antipsychotic medication, fasting blood sugar (FBS), serum triglyceride (TG), high de...

hdl can prevent ldl-c oxidation. the low hdl-c state also may benefit clinically from supplemented antioxidant. this study was designed to evaluate the combination therapy of statin and vitamin e in hypercholesterolemic patients. the patients were randomized in a clinical trial aimed to avaluate the effect of vitamin e and/or statin.the life style of patients didn't alter during intervention. t...

We examined the relation of longitudinal changes in cholesterol and triglyceride to the subsequent development of heart disease. The data were from 1437 participants of the Normative Aging Study, a prospective study of men from the Boston area who were free of ischemic heart disease on two examinations approximately 5 years apart. Forty-four had symptoms or ECG findings of ischemic heart diseas...

the present study aimed to assess changes in resting and maximum heart rates as primary indicators of cardiac autonomic function in metabolic syndrome (mets) patients and to determine their value for discriminating mets from non-mets. 468 participants were enrolled in this cross-sectional study and assessed according to the updated adult treatment panel iii (atp-iii) definition of mets. resting...

background: stroke is one of the most frequent causes of death and disability worldwide and has significant clinical and socioeconomic impact. hyperlipidemia and inflammation play major roles in atherothrombosis and in stroke. this study is conducted to compare the high sensitive c-reactive protein (hs-crp) levels and the lipid profile parameters between stroke patients and control group and de...

Obesity has dramatically increased in prevalence, making it essential to understand its accompanying metabolic changes. Modeling diet-induced obesity in Drosophila melanogaster (fruit flies), we elucidated transcriptional and metabolic changes in w (1118) flies on a high-fat diet (HFD). Mass spectrometry-based metabolomics revealed altered fatty acid, amino acid, and carbohydrate metabolism wit...