Due to growing concerns for environmental problems and food quality, consumers pay more attention the carbon emission freshness of fresh food. The booming e-commerce also accelerates development dual-channel supply chain. In chain food, are becoming important factors affecting consumers’ purchase demand. This paper focuses on optimal decision reduction pricing, which is investigated by a Stacke...

The environmental irritant chloroform, a naturally occurring small volatile organohalogen, briefly became the world’s most popular volatile general anesthetic (VGA) before being abandoned because of its low therapeutic index. When chloroform comes in contact with skin or is ingested, it causes a painful burning sensation. The molecular basis for the pain associated with chloroform remains unkno...

miR-17-92 is a microRNA cluster with six distinct members. Here, we show that the miR-17-92 cluster and its individual members modulate chronic neuropathic pain. All cluster members are persistently upregulated in primary sensory neurons after nerve injury. Overexpression of miR-18a, miR-19a, miR-19b and miR-92a cluster members elicits mechanical allodynia in rats, while their blockade alleviat...

The degenerin/epithelial sodium channel (DEG/ENaC) protein family includes related ion channel subunits from organisms ranging from the simple nematode Caenorhabditis elegans to humans. Members of this protein family have been implicated in functions as diverse as touch transduction and proprioception [1–4], pain sensation and maintenance of sodium balance [5]. Several blocks of sequence are co...

This paper proposes a new motivation for information sharing in a decentralized channel consisting of a single manufacturer and two competing retailers. The manufacturer provides a common product to the retailers at the same wholesale price. Both retailers add their own values to the product and distribute it to consumers. Factors such as retail prices, values added to the product, and local ad...

Abstract Cold-formed steel members with perforations have been commonly applied to meet the demands for technical installations. The design of perforated was regulated in Specification AISI S100-16 using Direct Strength Method (DSM). This method is based on elastic buckling analyses predict capacities cold-formed members. determination loads compulsory application DSM and has presented Specific...

This paper considers a dual-channel closed-loop supply chain consisting of manufacturer, retailer and collector in which the possesses private demand information determines whether to share his with other members. Specifically, we develop four sharing models, namely no (Model C–R), manufacturer C–R–M), revealing C–R–C), disclosing both C–R–T). We adopt Stackelberg game acquire equilibrium strat...