Background & Aim: The major problem of pharmaceutical industry for herbal product in current scenario is authentication of raw material, and availability of standards. The quality control and quality assurance of herbal drugs still remains a challenge because of the high variability of chemical components involved. Experimental: In present research work d...

The conditions under which, multilinear forms (the symmetric case and the non symmetric case),can be written as a product of linear forms, are considered. Also we generalize a result due to S.Kurepa for 2n-functionals in a group G.

Primitive mobile life forms, and the mobile cells of higher animals, derive their motivation and direct their navigation by chemical senses. In the simplest cases these creatures are hard-wired to swim toward nutrient concentration gradients, and to swim against irritant concentration gradients. The vestiges in humans of the sometimes extremely sensitive, selective, and differential chemical se...

The whole body retention, excretion, lung clearance, distribution, and concentration of 191Pt in other tissues was determined in rats following a single inhalation exposure to different chemical forms of 191Pt. The chemical forms of 191Pt used in study were 191PtCl4, 191Pt(SO4)2, 191PtO, and 191Pt metal. Immediately after exposure most of the 191Pt was found in the gastrointestinal and respirat...

Quantum chemical calculations based on density functional theory (DFT) method were performed on heterocyclic azole derivatives as corrosion inhibitors for mild steel in acid media to investigate the relationship between molecular structure of the inhibitors and the corresponding inhibition efficiencies (%). Quantum chemical parameters most relevant to their potential action as corrosion inhibit...

Asymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes. The recent exceptional advances in this area attest to a range of conceptual breakthroughs in chemical sciences in general, and to the p...

Chitosan, an aminopolysaccharide biopolymer, has a unique chemical structure as a linear polycation with a high charge density, reactive hydroxyl and amino groups as well as extensive hydrogen bonding. It displays excellent biocompatibility, physical stability and processability. The term 'chitosan' describes a heterogeneous group of polymers combining a group of physicochemical and biological ...

Directed evolution has become an important enabling technology for the development of new enzymes in the chemical and pharmaceutical industries. Some of the most interesting substrates for these enzymes, such as polymers, have poor solubility or form highly viscous solutions and are therefore refractory to traditional high-throughput screens used in directed evolution. We combined digital imagi...

BACKGROUND The identification of promising drug leads from a large database of compounds is an important step in the preliminary stages of drug design. Although shape is known to play a key role in the molecular recognition process, its application to virtual screening poses significant hurdles both in terms of the encoding scheme and speed. RESULTS In this study, we have examined the efficac...

Although the predictability of untoward drug effects in humans has improved in recent years, certain new drugs, with new pharmacological mechanisms, still pose a considerable challenge. This holds particularly true for biotherapeutics and their drug-related immune reactions, idiosyncratic drug hepatotoxicity and systemic toxicity. The selection of the 'right' animal models remains crucial; the ...