نتایج جستجو برای: childhood acute myeloid leukemia
تعداد نتایج: 833756 فیلتر نتایج به سال:
Acute leukemia is the most common childhood cancer and accounts for 31% of all cancers in children. There are two main types of acute leukemia. The most common is ALL (acute lymphoblastic leukemia) affecting the lymphoid lineage, and the more rare AML (acute myeloid leukemia) affecting the myeloid linage. The intention of this thesis is to follow the course of treatment from the admission to th...
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control studies in the Childhood Leukemia International Consortium. Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multi...
ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because lineage commitment hierarchies differ between embryo and adult, and the impact of oncogenes is cell-context dependent, we hypothesized that the childhood affiliation of ETV6-RUNX1 cALL reflects its origins in a progen...
Somatic mutations of TET2, IDH1, and IDH2 have been described in myelodysplastic syndrome. The impact of these mutations on outcome of myelodysplastic syndrome and their progression to secondary acute myeloid leukemia remains unclear. Mutation status of TET2, IDH1 and IDH2 was investigated in a cohort of 46 paired myelodysplastic syndrome/acute myeloid leukemia samples and 122 non-paired cases ...
acute myeloblastic leukemia is the most frequent cancer in adults and the patients have a wide range of sub-classes. hla dr negative cases represent one of the major immune-phenotypic classes. hla-dr is routinely used to distinguish acute promyelocytic leukemia (apl) from other aml subclasses based on the immunophenotype. the tgf-b signaling pathway, as a critical regulator, guides different v...
Concurrent development of acute myeloid leukemia (AML) and chronic lymphocytic (CLL) is very rare. We present a case simultaneous CLL AML in patient with no prior exposure to cytotoxic agents or irradiation.
abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. we report an 11 years old girl who developed central hypothyroidism and acth deficiency during the chemotherapy for cns relapse of acute lymphoblastic leukemia before receiving radiotherapy. keywords: thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leuk...
Spontaneous remission or regression of cancer is defined as partial or complete disappearance of malignant disease temporarily or permanently in the absence of any specific treatment. The condition is named spontaneous regression for solid tumors and spontaneous remission (SR) for leukemia [1]. Spontaneous remission has been reported in different hematological malignancies. It has been observed...
Measuring response to chemotherapy is a backbone of the clinical management of patients with acute leukemia. This task has historically relied on the ability to identify leukemic cells among normal bone marrow cells by their morphology. However, more accurate ways to identify leukemic cells have been developed, which allow their detection even when they are present in small numbers that would b...
Of all cancers in childhood (by WHO definition: O-14 year age group), leukemias constitute one of the most important groups of tumors. Our understanding of the biologic features of the childhood leukemias has increased greatly over the past decade. The ability to discern cytogenetic and molecular differences among morphologically and immunologically similar populations of leukemic cells has hel...
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