BACKGROUND Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity. OBJECTIVE Differing time schedules for childhood immunizations may explain the discrepant findings of an association with asthma reported in observational studies. T...

The role of repeated infections early in life in the development of childhood asthma and allergies has not been clarified. The aim of this study was to investigate the effect of repeated episodes of fever and antibiotic treatments during the first years of life on the prevalence of asthma, bronchial hyperresponsiveness (BHR), and atopy at school age in a representative population. Random sample...

Background Often preceded by early-life wheezing, asthma is the most common chronic disease of childhood. In view of the emerging microflora hypothesis of allergic disease, probiotics have been proposed for the prevention and treatment of allergic disorders including asthma, but clinical studies have yielded conflicting results. We undertook a systematic review and meta-analysis of randomized c...

OBJECTIVES Childhood adversities may be important determinants of later illnesses and poor health behaviour. However, large-scale prospective studies on the associations between childhood adversities and the onset of asthma in adulthood are lacking. DESIGN Prospective cohort study with 7-year follow-up. SETTING Nationally representative study. Data were collected from the Health and Social ...

Blackhali, M. I. (1970). Archives of Disease in Childhood, 45, 363. Ventilatory function in subjects with childhood asthma who have become symptom free. Ventilatory function was studied in 12 males who suffered from asthma in childhood, but who had been free of symptoms for an average period of 11 years. Though resting levels of FEV1 and the FEV1/FVC ratio were in most cases normal, an abnormal...

background: asthma is caused by the combination of different factors. current concepts of asthma pathogenesis emphasize on gene-environment interactions. mega-genome scanning projects revealed that different single nucleotide polymorphisms (snps) are related to asthma susceptibility. rs7216389-t is one of them that is related to childhood asthma and its effect on childhood asthma severity has b...

In India and around the globe, asthma is one of most prevalent chronic childhood disorders a major public health concern. It common in children aged 6-7, next 12- 13, finally 14-16. The frequency was considerably higher among individuals with family history asthma, smoking habits, where there lack smoke outlet house. By using identical homoeopathic treatments, it has shown overall results as co...

The primary health care team is at the forefront of asthma management and there is evidence of improved delivery of care via nurse run, audited, general practice clinics. However, hospital admissions for asthma continue to rise. Screening for childhood asthma would appear to have advantages for patient care. This review looks critically at the literature that addresses important issues in scree...

Atopic asthma is a complex disease associated with IgE-mediated immune reactions. Numerous genome-wide studies identified more than 100 genes in 22 chromosomes associated with atopic asthma, and different genetic backgrounds in different environments could modulate susceptibility to atopic asthma. Current knowledge emphasizes the effect of tobacco smoke on the development of childhood asthma. T...