We have successfully synthesized both enantiomers of a novel chiral ionic liquid, (R)- and (S)-[(3-chloro-2-hydroxypropyl) trimethylammonium][bis((trifluoromethyl)sulfonyl)amide] ((R)- and (S)-[CHTA]+[Tf2N]-) in optically pure form by a simple ion exchange reaction from corresponding chloride salts that are commercially available. In addition to the ease of preparation, this chiral IL has relat...

New chiral sulfoxide-1,3-oxazoline ligands have been developed as chiral ligands for Lewis acid-catalyzed asymmetric Diels-Alder reactions. The use of chiral sulfinyl 1,3-oxazoline ligands in copper(II)-catalyzed asymmetric Diels-Alder reactions provided an endo cycloadduct as a major product with moderate enantioselectivity. A rationale is proposed for the mechanism of the asymmetric induction.

The biological macromolecular world is homochiral and effective enforcement and perpetuation of this homochirality is essential for cell survival. In this study, we present the mechanistic basis of a configuration-specific enzyme that selectively removes D-amino acids erroneously coupled to tRNAs. The crystal structure of dimeric D-aminoacyl-tRNA deacylase (DTD) from Plasmodium falciparum in co...

‘Constituent quarks’ means massive quarks, in contrast to the nearly massless u, d, s quarks of the QCD lagrangian. The dynamical or constituent masses appear owing to the spontaneous chiral symmetry breaking in QCD. A realistic mechanism of the chiral symmetry breaking is provided by instantons. Therefore, I review the present status of the QCD instanton vacuum, emphasizing the mechanism of ch...

A common approach in resolving enantiomers of chiral basic drugs by capillary electrophoresis (CE) is to use cyclodextrins (especially their anionic derivatives) as chiral selector in the acidic buffer (pH ≤ 3) in normal or reversed (carrier) mode. Then, some organic modifiers are added to the buffer solution if the resolution is not satisfactory. In case of cetirizine (CTN), applying the same ...

In the present paper, the expressions for scalar and vector potentials in lossless isotropic chiral media are analyzed. Propagating eigenvalues of these potentials are then obtained. Furthermore by decomposition of sources and fields in a chiral medium, we introduce the auxiliary right-and left-handed potentials and find the associated fields. These potentials are used to solve the problem of a...

Enantiomers of chiral biomolecules and drugs have distinct pharmacological and toxicological activities. . Consequently, separation and determination of enantiomers are vital in pharmaceutical and chemical industries. It is wellknown that the l-enantiomer of oligopeptides naturally exists in the organism; however, d-oligopeptides are regarded as potential therapeutic agents because of their res...

Spontaneous asymmetric generation of supramolecular chiral fibers was observed in the folding induced self-assembly of a lock-washer shaped foldamer. A secondary nucleation growth mechanism is proposed to explain the observed chiral amplification or deracemization of these supramolecular fibers.