In eukaryotes, the transcription of tRNA genes is initiated by the concerted action of transcription factors IIIC (TFIIIC) and IIIB (TFIIIB) which direct the recruitment of polymerase III. While TFIIIC recognizes highly conserved, intragenic promoter elements, TFIIIB binds to the non-coding 5'-upstream regions of the tRNA genes. Using a systematic bioinformatic analysis of 11 multicellular euka...

Mendes IAC, Ventura CAA. Nursing Protagonism in the UN Goals for the people’s health. Rev. Latino-Am. Enfermagem. 2017;25:e2864. [Access ___ __ ____]; Available in: ____________________. DOI: http://dx.doi. org/10.1590/1518-8345.0000.2864. URL day month year For decades, high-level discussions on possible actions and strategic goals have been conducted aiming at achieving a better level of heal...

BACKGROUND AND PURPOSE Pathogenetic classification of intracerebral hemorrhage (ICH), using systems such as SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy [CAA], systemic disease, hypertension, or undetermined), is important in predicting functional outcomes and mortality in patients with ICH. This study aimed to compare pathogenetic subtypes between the first and...

Mature RNA transcripts from a single eukaryotic gene may contain different nucleotide sequences, ranging from alternately spliced exons to transcripts from separate alleles differing by only one base. Our laboratory and others have recently reported another class of RNA sequence differences, occurring in transcripts from the single copy apolipoprotein B (apoB) gene. A unique RNA editing mechani...

Direct numerical simulation results of aeolian tones generated by a two-dimensional obstacle (circular cylinder, square cylinder, NACA0012 airfoil) in a uniform flow are presented and the generation and propagation mechanisms of the sound are discussed. The unsteady compressible Navier-Stokes equations are solved by a highly-accurate finite difference scheme over the entire region from near to ...

Outdoor Air Quality OAQ): The federal government has made great progress towards cleaning outdoor air since 1970 via the Clean Air Act (CAA) and its additional amendments signed into law in 1990. This Act resulted in a significant 70% reduction of aggregate emissions of six representative indicators of common pollutants between the years of 1970 to 2014! Thusly, the CAA laws define the EPA’s re...

Immunohistochemical study of perivascular plaques (PPs) in 7 patients with Alzheimer's disease (AD) and 4 with cerebral amyloid angiopathy (CAA)(CAA with dementia in 3 patients and CAA with massive cerebral hemorrhage in 1 patient) demonstrated that PPs were also a common form of amyloid P (AP) deposits, like SPs and CAAs, in both AD and CAA, and that they had similar immunostaining characteris...

Ten histologic sections were sampled from similar cortical regions in each of 84 autopsy brains removed from patients aged 60 to 97 years. The sections were stained by the Congo-red method and examined under polarized light for the presence of cortical {parenchymal) cerebral amyloid angiopathy (CAA). Some degree of CAA was found in 36% of all brains examined, with a higher proportion of patient...

The rutschblock test is one of the most reliable snow stability tests. It is a mini slab avalanche that is tested with the appropriate dynamic load: the skier or snowboarder. The test method and its limitations are reviewed. The application of the rutschblock test as the standard stability test in the observational network of the Swiss Avalanche Warning Service is described. Introduction The ru...

Quantitative RT-PCR analysis. The following primers were used to amplify β-casein cDNA and 18S rRNA sequences: forward primer of the β-casein gene 5'-GCT CAG GCT CAA ACC ATC TC-3' and reverse primer 5'-TGT GGA AGG AAG GGT GCT AC-3'; forward primer of the 18S rRNA gene 5’-TCGGAACTGAGGCCATGATT-3’ and reverse primer 5’CCTCCGACTTTCGTTCTTGATT-3’. Fragments of β-casein gene and 18S rRNA were amplifie...