Recent investigations have provided evidence that the release and removal of acetylcholinc is an intracellular process directly connected with the nerve action potential. The experiments suggest that the ester renders the neuronal surface permeable to all ions and thereby depolarizes the membrane (l-4). This concept is based mainly on studies of the enzyme cholinesterase. Three essential featur...

abstract pollution is a world problem with serious consequences. heavy metals are an important group of these contaminants and enter aquatic ecosystems from anthropogenic and natural sources and animal health and systems are affected. in this study, the effect of lead exposure (3 mg/l concentration, 30 days) on activity of tissue enzymes, including acetyl cholinesterase, alanine aminotransferas...

ABSTRACT: Androgenetic alopecia is the chief type of scalp hair loss regardless of gender, causing anxiety, depression, arterial stiffness, and cardiovascular disease. The areal parts of Olea europaea (OE) and Trigonella foenum-graecum (TF), as well as the bulbs of Allium sativum (AS) are vastly used in Persian folklore for a great range of culinary and medicinal purposes. This study was an att...

Phytochemical investigation on the bark of Nauclea officinalis led to isolation a new monoterpenoid indole alkaloid, nauclediol. The structure compound was identified through extensive spectroscopic analysis. Nauclediol displayed cholinesterase-inhibitory activities towards AChE and BChE with IC50 values 15.429 8.756 µM, respectively. Statistical analysis revealed that mode inhibition naucledio...

"Nonspecific" cholinesterase (acylcholine acylhydrolase; EC 3.1.1.8) from various rat tissues has been found to exist in several stable molecular forms that appear as exact counterparts of molecular forms of acetylcholinesterase (acetylcholine hydrolase; EC 3.1.1.7). The sedimentation pattern of cholinesterase was similar to that of acetylcholinesterase with a small but significant shift betwee...

Cholinesterase and succinyldehydrogenase activity of surgically removed left atrial auricles from patients in atrial fibrillation and in sinus rhythm have been compared, using histochemical methods. Higher cholinesterase and lower succinyldehydrogenase activity has been found in atrial fibrillation than in sinus rhythm. The pulmonary capillary mean pressure of patients with atrial fibrillation ...