Neutrophils play an important role in the human immune system for protection against such microorganisms as a protozoan parasite, Trichomonas vaginalis; however, the precise role of neutrophils in the pathogenesis of trichomoniasis is still unknown. Moreover, it is thought that trichomonal lysates and excretory-secretory products (ESP), as well as live T. vaginalis, could possibly interact with...

Trichomonas vaginalis induces apoptosis in host cells through various mechanisms; however, little is known about the relationship between apoptosis, reactive oxygen species (ROS), and NF-κB signaling pathways in the cervical mucosal epithelium. Here, we evaluated apoptotic events, ROS production, and NF-κB activity in T. vaginalis-treated cervical mucosal epithelial SiHa cells, with or without ...

OBJECTIVE In this study, the cytopathic effects of Trichomonas vaginalis were investigated in L929 mouse fibroblast cell cultures (FCC) under different conditions: only parasite, or coexistence with Candida albicans and Escherichia coli. METHODS The parasite was isolated from a symptomatic patient and cultured in Cysteine-Peptone-Liver infusion Maltose medium (CPLM). C. albicans strain 10235 ...

Trichomoniasis, caused by the parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually-transmitted disease, and there can be severe complications from trichomoniasis. Antibiotic resistance in T. vaginalis is increasing, but there are currently no alternatives treatment options. There is a need to discover and develop new chemotherapeutic alternatives. Plant-derived natur...

Variables affecting the adherence of Gardnerella vaginalis to human vaginal epithelial cells were examined in vitro. Adherence depended on pH, with maximum attachment occurring between pH 5 and pH 6. Preincubation of the bacteria at 56 degrees C for 30 minutes and ultraviolet irradiation resulted in a noticeable decrease in adherence. In contrast, adherence was not altered by preincubating the ...

Gardnerella vaginalis was isolated from 22 (38%) of 58 semen samples obtained from men attending an infertility clinic. Counts ranged from 1.2 X 10(3) to greater than 10(7) colony forming units (cfu)/ml. There was no association between the isolation of G vaginalis and the sperm count. Twenty (34.4%) samples contained non-sporing anaerobes and nine (15.5%) both anaerobes and G vaginalis. The in...

TO THE EDITOR—Schwebke et al [1] present a conceptual model arguing the case for Gardnerella vaginalis as the primary etiological agent of bacterial vaginosis (BV). The model posits that G. vaginalis is a sexually acquired pathogen that elicits BV via the establishment of a bacterial biofilm on the vaginal epithelium, aided by synergistic associations with vaginal anaerobes and competitive inte...

To investigate the effect of drugs other than metronidazole, 3 non-pregnant women infected with Trichomonas vaginalis were treated with doxycycline, 2 x 200 mg/day for 1 week. Another 3 women were treated with praziquantel, single dose, 40 mg/kg body weight. No therapeutic effect was detected for either drug. In vitro, oxytetracycline led to death of T. vaginalis at a concentration of 15 mg in ...

Trichomonas vaginalis, a causative agent of trichomoniasis, may trigger symptomatic or asymptomatic nongonococcal urethritis and chronic prostatitis in men. Despite the availability of highly sensitive diagnostic tests, such as nucleic acid amplification tests, including PCR, few prospective studies present data on male T. vaginalis infection in South Korea. In the present study, the prevalence...

Problem statement: Both M. genitalium and T. vaginalis were recognized as important cause of sexually transmitted infections in developed countries. This study investigated the prevalence of M. genitalium and T. vaginalis in general Jordanian patients and their role of causing genitourinary tract diseases. Approach: A cross sectional study of 383 Jordanian adult patients aged between 19-78 year...