abstract background: transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. this study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration. methods: in a c...

An autosomal dominant dysplasia-malformation syndrome affecting seven individuals in one family is reported. The components of the syndrome include congenital nasopalpebral lipoma, telecanthus, and bilateral colobomas of upper and lower lids without midface hypoplasia. It appears to be the second recorded example resulting from an autosomal dominant gene fully penetrant in both sexes.

purpose : to report the evaluation of the treatment response in choroidal hemangioma with application of enhanced depth imaging optical coherence tomography (edi-oct) technique case report : a 73-year-old woman with a circumscribed choroidal hemangioma in the posterior pole of her left eye underwent photodynamic therapy and intravitreal injection of bevacizumab. edi-oct obtained from the affect...

purpose: to evaluate the outcomes and complications of phacoemulsification and posterior chamber intraocular lens implantation (pe+pciol) in patients with congenital iris coloboma. methods: in a prospective noncomparative interventional case series, 13 eyes of 9 patients (six female and three male) with congenital iris coloboma and cataract underwent pe+pciol using clear corneal incision and in...

Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newbo...

CHARGE syndrome was initially defined as a non-random association of anomalies (Coloboma, Heart defect, Atresia choanae, Retarded growth and development, Genital hypoplasia, Ear anomalies/deafness). In 1998, an expert group defined the major (the classical 4C's: Choanal atresia, Coloboma, Characteristic ears and Cranial nerve anomalies) and minor criteria of CHARGE syndrome. Individuals with al...

EDITOR,—Doubling of the optic disc is rare and can manifest as true or pseudo doubling. A 64 year old man was referred by his physician who noted “a clear area between each optic disc on both sides” during a routine check. Visual acuities and anterior segments were normal. Funduscopy revealed an appearance simulating double optic discs on each side. The right eye showed a 2 disc diameter (DD) s...

Coloboma is a congenital disease that contributes significantly to childhood blindness. It results from the failure in closing the optic fissure, a transient opening on the ventral side of the developing eye. Although human and mouse genetic studies have identified a number of genes associated with coloboma, the detailed cellular mechanisms underlying the optic fissure closure and coloboma form...

IMPORTANCE Microphthalmia, anophthalmia, and coloboma form an interrelated spectrum of congenital eye abnormalities. OBJECTIVE To document the ocular and systemic findings and inheritance patterns in patients with microphthalmia, anophthalmia, and coloboma disease to gain insight into the underlying developmental etiologies. DESIGN, SETTING, AND PARTICIPANTS This retrospective consecutive c...

BACKGROUND Indocyanine green video-angiography is a recently popularised technique for imaging the retina and choroid. Little is known about the value of this technique in the evaluation of choroidal tumours. METHODS Indocyanine green video-angiograms of 51 patients with choroidal tumours, including 32 with choroidal melanoma, five with choroidal naevus, four with choroidal metastasis, four w...