background nephrotoxicity is characterized and scored by many parameters such as vacuolization, dilatation, hyaline cast, debris or degeneration in injured renal tissue. in this short report, we attempt to find, the most correlated parameters with kidney tissue pathology damage score (pds) in cisplatin-induced nephrotoxicity. method a total of 207 normal and toxic rats’ kidney tissue (induced b...

background: the prognosis of patients with decompensated cirrhosis due to hepatitis b is very poor. it has been shown that lamivudine can improve liver function and delay the need for liver transplantation in hbeag-positive patients with decompensated cirrhosis. however, information regarding long-term use of lamivudine in hbeag-negative patients with cirrhosis is limited. the primary objective...

â background: hepatitis b is still a major health problem in many parts of the world. in some developing countries the most common cause of chronic hepatitis and liver cirrhosis is hepatitis b virus (hbv). the progression of chronic hepatitis b to cirrhosis andâ  hepatocellular carcinoma (hcc) include such viral factors as genotype c and high levels of serum hbv dna in addition to host factors ...

prohibitins are chaperone proteins highly conserved among eukaryotes. many different functions have been attributed to prohibitins depending on their tissue expression and sub-cellular localization. prohibitins play a major role in mitochondrial physiology, regulating the stability and the processing of both respiratory chain complex subunits and opa1, a mitochondrial fusion regulating protein....

abstract background: chronic illnesses such as coronary heart disease are among the most prevalent and costly of all global health problems. coronary heart disease is a leading cause of death worldwide, including iran. one aspect of living with chronic illness is self-management which can reduce the impact of illness on daily life and maintain the quality of life. a qualitative understanding of...

abstract background: the children with middle ear effusion need repeated re-tympanostomies. adenoidectomy is an effective surgical intervention in the management of chronic otitis media with effusion in conjunction with in-sertion of tympanostomy tubes (tts). to find out whether tts in different positions decrease the rate of re-tympanostomies study was done. methods: the present study retrospe...

background despite significant advances in the treatment of chronic hepatitis c in the past decades, factors which can affect response rates to combination therapy; peginterferon and ribavirin, are still under study and reaching sustained virological response (svr) is affected by several different factors. objectives to investigate predictor factors contributing to svr in iranian patients. pati...

background: hearing loss due to chronic otitis media is common. the purpose of this study was to evaluate hearing before and after canal wall up, canal wall down mastoidectomy and tympanoplasty. methods: from 2004 to 2007, all patients with chronic otitis media who were admitted at the department of otolaryngology, babol medical university were studied. for 126 patients' canal wall up, can...

introduction: the aim of this study was to evaluate the condition of the ossicular chain in patients requiring surgery for cholesteatoma.  materials and methods: in a retrospective analysis, the destruction of the individual and combined bony structures of the ear was described in 166 patients with cholesteatoma who went through surgery in our otology center between 2003 and 2009.  results: tot...