نتایج جستجو برای: chronic granulomatous disease

تعداد نتایج: 1773348  

Journal: :The Netherlands journal of medicine 2011
F L van de Veerdonk M G Netea C A Dinarello J W M van der Meer

Journal: :Medical Immunology 2006
Tracy Assari

It has been 50 years since chronic granulomatous disease was first reported as a disease which fatally affected the ability of children to survive infections. Various milestone discoveries from the insufficient ability of patients' leucocytes to destroy microbial particles to the underlying genetic predispositions through which the disease is inherited have had important consequences. Longterm ...

Journal: :JAMA otolaryngology-- head & neck surgery 2014
Eileen M Raynor

IMPORTANCE In the limited number of Crohn disease cases involving the head and neck, there is a predilection for mucosal surfaces and rare reports of involvement in the postauricular region. To our knowledge, in all previously reported cases involving the head and neck, the patients had a known diagnosis of Crohn disease. OBSERVATIONS This case describes a 10-year-old boy with a history of ps...

Journal: :medical journal of islamic republic of iran 0
farzaneh ebrahimi-fard shahid baheshti university of medical sciences and health servicesسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) arash najaf beygi shahid beheshti university of medical sciencesسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) ali kavyani shahid beheshti university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) amirhosein jalali shahid beheshti university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

absract idiopathic granulomatous mastitis is a rare, inflammatory, and benign breast disease characterized by non-caseating granulomata and microabscesses limited to breast lobules. this condition presents as a firm breast mass that is clinically and radiologically indistinguishable from breast cancer, or as multiple or recurrent abscesses, or mastitis in a young non-lactating woman. almost alw...

Journal: :Circulation 2010
Stavros P Loukogeorgakis Merlijn J van den Berg Reecha Sofat Dorothea Nitsch Marietta Charakida Bu'Hussein Haiyee Eric de Groot Raymond J MacAllister Taco W Kuijpers John E Deanfield

BACKGROUND Reactive oxygen species have been implicated in the pathogenesis of ischemia/reperfusion (IR) injury. Recent studies suggest that NADPH oxidase may be a source of ROS during IR. Using an in vivo model of endothelial IR injury in the arm, we compared the response to IR in healthy volunteers with that in patients with chronic granulomatous disease. These patients have a molecular lesio...

2010
Stavros P. Loukogeorgakis Reecha Sofat Raymond J. MacAllister Taco W. Kuijpers

Background—Reactive oxygen species have been implicated in the pathogenesis of ischemia/reperfusion (IR) injury. Recent studies suggest that NADPH oxidase may be a source of ROS during IR. Using an in vivo model of endothelial IR injury in the arm, we compared the response to IR in healthy volunteers with that in patients with chronic granulomatous disease. These patients have a molecular lesio...

Journal: :Journal of investigational allergology & clinical immunology 2011
D Hanoglu T T Ozgür D Ayvaz M Y Köker O Sanal

Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder caused by inherited defects in the nicotinamide adenine dinucleotide phosphate oxidase complex. The neutrophils of patient with CGD can ingest bacteria normally, but the oxidative processes that lead to superoxide anion formation, hydrogen peroxide production, nonoxidative pathway activation, and bacterial killing are im...

2013
Bernard M. Babior

The kinetics of activation of the respiratory burst oxidase in the cell-free oxidase-activating system have been explained by a three-stage mechanism in which the membrane-associated oxidase components M: (a) take up a cytosolic factor S to form a complex M S that is (b) slowly converted in the second stage to a precatalytic species [M*S]*, which finally (c) takes up two more (possibly identica...

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