Background Familial Mediterranean fever (FMF) is an autoinflammatory disorder, characterized by short attacks of sterile serositis, successfully suppressed by continuous colchicine treatment. Subclinical chronic inflammation however, is a frequent finding in FMF, manifested with elevated levels of inflammatory markers (CRP, SAA). While chronic inflammation is considered an important cardiovascu...

From the histologic point of view ‘colitis’ is microscopic inflammation of the colon. Colitis may be acute or chronic, diffuse or focal based on the etiological factor(s) and the type and distribution of the inflammatory infiltrate that prevails in the colon. Very often the pathologist encounters acute inflammation superimposed on chronic inflammation; this may be indicative of an acute exacerb...

Neutrophils are granulocytic cytotoxic leukocytes of the innate immune system that activate during acute inflammation. Neutrophils can also persist beyond the acute phase of inflammation to impact the adaptive immune response during chronic inflammation. In the context of the autoimmune disease, neutrophils modulating T and B cell functions by producing cytokines and chemokines, forming neutrop...