Clan CD cysteine peptidases, a structurally related group of peptidases that include mammalian caspases, exhibit a wide range of important functions, along with a variety of specificities and activation mechanisms. However, for the clostripain family (denoted C11), little is currently known. Here, we describe the first crystal structure of a C11 protein from the human gut bacterium, Parabactero...

OBJECTIVES This study investigates work performance among 79 mental health teams in Quebec (Canada). We hypothesized that work performance was positively associated with the use of standardized clinical tools and clinical approaches, integration strategies, "clan culture," and mental health funding per capita. METHODS Work performance was measured using an adapted version of the Work Role Que...

An analytical framework was developed for explaining the conditions for the effectiveness of different strategies promoting integrated primary health-care (PHC) service-based systems in Latin-America. Different modes of governance (clan, incentives and hierarchy) were characterised from a political economics viewpoint for representing alternative forms of regulation promoting innovation in heal...

The main goal is to illustrate that the so-called indirect function of a cooperative game in characteristic function form is applicable to determine the nucleolus for a subclass of coalitional games called compromise stable TU games. In accordance with the Fenchel-Moreau theory on conjugate functions, the indirect function is known as the dual representation of the characteristic function of th...

as turkey is officially a secular state and it adopts swiss civil code, thestate implements secular legal system. however, as people in turkey are predominantlymuslim and theyare born and raised in a traditionally muslim environment,people generally and especially women live under the influence of these two sometimescontradictory and inconsistent legal systems and customs. as a result, thereare...

Caspases have several allosteric sites that bind small molecules or peptides. Allosteric regulators are known to affect caspase enzyme activity, in general, by facilitating large conformational changes that convert the active enzyme to a zymogen-like form in which the substrate-binding pocket is disordered. Mutations in presumed allosteric networks also decrease activity, although large structu...

In this article we introduce a computational procedure, OPTCOMB (Optimal Pattern of Tiling for COMBinatorial library design), for designing protein hybrid libraries that optimally balance library size with quality. The proposed procedure is directly applicable to oligonucleotide ligation-based protocols such as GeneReassembly, DHR, SISDC, and many more. Given a set of parental sequences and the...